Genome-wide approaches

Strategies to Identify Pharmacogenomic Biomarkers Candidate Gene, Pathway-Based, and Genome-Wide Approaches... 

Tavera-Mendoza LE, Mader S, White JH. Genome-wide approaches for identification of nuclear receptor target genes. Nucl. Recept. Signal. 2006 4 e018. 

Genome-Wide Approaches to Study Chromatin Modifications... 

Schones, D. E., and Zhao, K. (2008). Genome-wide approaches to studying chromatin modifications. Nat Rev Genet 9(3), 179-191. 

Candidate Gene versus Genome-Wide Approaches... 

Nelson MR, Bacanu SA, Mosteller M, Li L, Bowman CE, Roses AD, Lai EH, Ehm MG (2009) Genome-wide approaches to identify pharmacogenetic contributions to adverse drug reactions. Pharmacogenomics J 9 23-33... 

Protein microarray technology provides a platform for the in vitro study of protein function at a genome-wide level (Talapatra et al. 2002). Immobilized proteins can be assayed in parallel under many different conditions and with many different samples. However, whole-proteome microarrays are difficult to achieve for higher organisms. Until recently, they have been limited to studies of the yeast proteome because production of a large number of pure recombinant proteins in parallel is a tedious and expensive process. cDNAs must be cloned into expression vectors, and the translated proteins must be purified in large amounts. Furthermore, in the case of genome-wide approaches, the cDNA library must be normalized. 

Genome Wide Approaches in Natural Product Research... 

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