Gene therapy basic approach

Penuelas I, Boan J, Marti-Climent J M, et al. (2004). Positron emission tomography and gene therapy Basic concepts and experimental approaches for in vivo gene expression imaging. Molec. Imag. Biol. 6 225-238. 

Theoretically, a number of other diseases affecting the pulmonary interstitium might be treated with gene therapy. These include interstitial pneumonitides and idiopathic pulmonary fibrosis. These approaches will depend upon further advancements in the study of the basic pathobiology of these disorders. 

Basic approach to gene therapy The basic approach to gene therapy involves (Figure 1.12) ... 

The adrenal cortex plays a key role in regulating intermediary metabolism, fluid and electrolyte balance, and the response to stress. Molecular analyses of specific disorders resulting from either the diminished or enhanced produc-tion/action of corticosteroids have led to the identification of a number of genes that play key roles in adrenal function and corticosteroid action. These genes provide potential targets for novel therapies that may revolutionize our approaches to these rare adrenal diseases. In addition, understanding the molecular causes of these diseases has provided important insights into basic adrenal functions that may translate into improved therapy of more common disorders such as hypertension and obesity. 

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