Candidate Gene Studies

Greenberg, B. D., McMahon, F. J. et al. (1998). Serotonin transporter candidate gene studies in affective disorders and personality promises and potential pitfalls. Mol. Psychiatry, 3(3), 186-9. 

As the number of SNPs evaluated in an association study increases, a concern arises with false positives. This is true for candidate gene studies, but moreso for whole genome random SNP studies where tens to hundreds of thousands of SNPs will be evaluated. The traditional cutoff for assessing statistical significance (p<0.05] by definition can result in 5% false associations occurring simply by... 

Metabolism of Other Pharmacologically Active Compounds by Cytochrome P450 Enzymes 449 Future Targets for Candidate Gene Studies 450 Genome Scans to Investigate Tobacco Dependence 450 Genomic Areas Linked with Susceptibility to Nicotine Dependence 451... 

In the candidate-gene approach - the most frequently used approach adopted to identify the predisposing or causal genes in the complex and multigenic and multifactorial diseases - genes with a known or proposed function, with the potential to influence the disease phenot)q)e, are investigated for a direct role in disease. In a small number of cases of t)q)e 2 diabetes, candidate-gene studies have identified mutations in. 

V. Gene Expression During Sleep Deprivation and Recovery Sleep Candidate Gene Studies... 

Lerer B, Macciardi F. Pharmacogenetics of antidepressant and mood-stabilizing drags a review of candidate-gene studies and future research directions. Int J Neuropsychopharmacol 2002 5 255-275. 

One limitation of candidate gene studies is that the genes must be defined in advance having prior information about their role in the trait being... 

Most genetic studies so far have been candidate gene studies, in which the frequency of different genotypes at a specific locus or loci within a gene or genes thought likely to be in... 

While candidate gene studies have provided an insight into the role of established pharmacokinetic and pharmacodynamic targets in antipsychotic treatment response (Table 3), these studies are restricted to our current limited understanding of antipsychotic mechanisms of action. An alternative approach is the use of genome-wide association studies (GWAS), which investigate the... 

Tsai HT, Caroff SN, Miller DD, McEvoy J, Lieberman JA, North KE et al (2010) A candidate gene study of tardive dyskinesia in the CATIE schizophrenia trial. Am J Med Genet B Neuropsychiatr Genet 153B 336-340... 

Osteoporosis is a prevalent disease that typically reduces bone strength and predisposes to fractures. It is a multifactorial disorder resulting from the interaction of genetic and acquired factors. Candidate gene studies and, more recently, genome-wide studies have identified a number of polymorphisms significantly associated with bone mass and fractures. Anti-resorptive drugs, which inhibit the differentiation and activity of osteoclasts, are frequently used to treat patients with osteoporosis. 

The influence of genetic polymorphisms on the response to antiosteoporosis therapy has been explored in a number of candidate gene studies (see recent reviews [17-20]), but the results have rarely been replicated. 

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