The candidate-gene approach

The candidate gene approach directly tests the association of selected genes with drug response or ADR. The major sources of candidates which code for receptor, enzyme or ADME targets, are obtained through literature surveys. Most pharma-... 

E. The Candidate Gene Approach for Identifying Risk Genes... 

In the candidate-gene approach - the most frequently used approach adopted to identify the predisposing or causal genes in the complex and multigenic and multifactorial diseases - genes with a known or proposed function, with the potential to influence the disease phenot)q)e, are investigated for a direct role in disease. In a small number of cases of t)q)e 2 diabetes, candidate-gene studies have identified mutations in. 

Besides the examples listed above, there are numerous exploratory association studies that have identified many potential polymorphism biomarkers for treatment response in membrane transporter, drug-metabolizing enzyme, and drug target genes. The methodology and statistical analysis for the candidate gene approach are simple the results are easy to interpret. 

Pflieger, S., Lefebvre, V., and Causse, M. 2001, The candidate gene approach in plant genetics a review,Mol. Breeding 7 275-291. 

Buckland RR. (2001) Genetic association studies of alcoholism — problems with the candidate gene approach. Alcohol Alcohol. 36, 99-103. 

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