Fungi Aspergillus terreus

Synonym Micrococcus glutamicus) Brevibacterium flavum Brevibacterium divaricatum Fungi Aspergillus terreus Ustilago maydis... 

Comasseto JV. Omori AT, Andrade LH, Porto ALM. Bioreduction of fluoroacetophenones by the fungi Aspergillus terreus and Rhizopus oryzae. Tetrahedron Asymm. 2003 14 711-715. 

It is well known that certain microorganisms are able to effect the deracemization of racemic secondary alcohols with a high yield of enantiomerically enriched compounds. These deracemization processes often involve two different alcohol dehydrogenases with complementary enantiospedficity. In this context Porto ef al. [24] have shown that various fungi, induding Aspergillus terreus CCT 3320 and A. terreus CCT 4083, are able to deracemize ortho- and meta-fluorophenyl-l-ethanol in good... 

Low-Molecular Weight Xylanase Inducers. The response of cellulolytic fungi to low-molecular weight fragments of xylan and ceUulose confirmed the separate regulatory control of the formation of xylanases and ceUulases. Xylobiose [Xylp-p-(l- 4)-Xylp] was a specific inducer of xylanases in T. reesei (61) and Aspergillus terreus (67). Sophorose and otho glucobioses selectively induced the synthesis of... 

Some plant-derived drugs come from lower organisms, such as fungi (e.g., the antihyperlipidemic agent lovastatin from Aspergillus terreus and the immunosuppressant cyclosporin from Beauveria nivea) whereas others are obtained from higher plants (see Table 5.3 and Table 5.4). 

Itaconic acid is a bifunctional monomer obtained by the fermentation process using Aspergilius itaconicus and Aspergillus terreus fungi [182,183],... 

Less is known about the pathways of PAH degradation by co-cultures than about the pathways of degradation by individual bacteria and fungi (Juhasz Naidu, 2000). Four bacteria Pseudomonas aeruginosa, Pseudomonas cepacia (=Burkholderia cepacia). Pseudomonas sp. and Ralstonia pickettii) and four fungi (Alternaria tenuis, Aspergillus terreus, Trichoderma... 

Lovastatin and mevastatin are synthesized via polyketide pathways. Polyketides are a large group of structurally diverse secondary metabolites produced by bacteria, fungi, and plants. The factors influencing production of lovastatin or mevastatin have not been fuUy elucidated. Studies of Aspergillus terreus grown in chemically defined media indicate that... 

Many attempts have been made to find cholesterol biosynthesis inhibitors for development as hypocholesterolemic agents. Microbial secondary metabolites have been used as valuable natural sources in the development of novel cholesterol biosynthesis inhibitors. Mevastatin and lovastatin were isolated from the fungi, Penicillium citrinum and Aspergillus terreus, respectively, as potent inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase which is involved in the rate-limiting step of cholesterol synthesis in mammals. These findings have led to the development of statins , which are drugs of choice in the treatment of hypercholesterolemia. 

The presumed biosynthetic precursor of 6-methoxymellein, 6-hydroxymellein (10), has also been isolated from carrot roots stored under stress (ref.32). This compound was first isolated from a mutant of Aspergillus terreus (ref.42) and subsequently has been found in the bar)c of Tabebuia avellanedae (ref. 43) and produced by the fungi Pyricularla oryzae (ref. 44) and Ceratocystis minor (ref.45). Recently, the ( + )-6-hydroxymellein isomer has been isolated from the flowers of Cassia siamea (ref.46) and from a fungus of the genus Discula (ref.47). 

Statins are the secondary metaboKtes of a number of different filamentous fungi. Their medical importance and commercial value stem from their ability to inhibit the enzyme (3S)-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase. Since this enzyme catalyzes a key step in the endogenous cholesterol biosynthetic pathway, statins have become the widely used an-tihypercholesterolemic drugs. Along with some synthetic statins, the most prominent examples are lovastatin, mainly from Aspergillus terreus, and mevastatin produced by Penicillium citrinum, which was the first statin to be discovered [92, 93]. 

For (i ,/ )-form see Threitol, T-100. Opt. inactive (meso-) some derivs. may be chiral (see for example 5-Hydroxy-2-phenyl-l,3-dioxane-4-methanol, H-193). Found in a variety of algae, lichens and fungi. Prod, by Protococcus vulgaris, Trentepohlia iolithus and Aspergillus terreus. Bulk sweetener with good taste props. Also thickenei stabiliser, humectant, etc. in food. Cryst. (MeOH). Mp 121.5°. Bp 329-331° Bpjoo 294-296°. Sweetness ca. 0.7 x sucrose. 

Aspergillus terreus Fungi Cited 100% inh. 600 Shukla and Tripathi (1987)... 

Hevekerl, A., Kuenz, A., and Vorlop, K.-D. (2014) Filamentous fungi in microtiter plates-an easy way to optimize itaconic acid production with Aspergillus terreus. AppL Microbiol. BiotechnoL, 98, 6983 -6989. 

FIG. 12 Kinetic curves of adhesion of different fungi to polyethylene surface. 1 Aspergillus niger, 2 Penicillium cyclopium 3 Paec. varioti 4 Penicillium chrysogenium 5 Aspergillus terreus. 

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