Aspergillus terreus

Aspergillus ocraceus Aspergillus oryzae Aspergillus parasiticus Aspergillusrugulosus Aspergillus sydowi Aspergillus terreus... 

It was originally thought that microbial fermentation by Aspergillus terreus followed a similar pattern in that dtric add - produced by glycolysis plus the bridging reaction and two Dathwavs rst reaction of the TCA cyde - was converted to aconitic add. This compound was... 

It is well known that certain microorganisms are able to effect the deracemization of racemic secondary alcohols with a high yield of enantiomerically enriched compounds. These deracemization processes often involve two different alcohol dehydrogenases with complementary enantiospedficity. In this context Porto ef al. [24] have shown that various fungi, induding Aspergillus terreus CCT 3320 and A. terreus CCT 4083, are able to deracemize ortho- and meta-fluorophenyl-l-ethanol in good... 

It was proposed that a Diels-Alder cyclization occurred during a polyketide synthase assembly of the bicyclic core of Lovastatin by Aspergillus terreus MF 4845." In vitro Diels-Alder cyclization of the corresponding model compounds generated two analogous diastere-omers in each case, under either thermal or Lewis-acid-catalyzed conditions (Eq. 12.37). As expected, the Diels-Alder reaction occurred faster in aqueous media. The cyclization half-life in chloroform at room temperature is 10 days while in aqueous media at either pH 5 or 7, the half-life drops to two days. 

Kumar, A.K. and Goswami, P. (2006) Functional characterization of alcohol oxidases from Aspergillus terreus MTCC 6324. Applied Microbiology and Biotechnology, 72, 906-911. 

Aspergillus alliaceus Aspergillus terreus Baeuveria bassiana Circinella minor Cunninghamella bertholletiae... 

The utility of electroreductive cyclization chemistry is demonstrated quite nicely in its application to a formal total synthesis of quadrone (59) [41]. This fungal metabolite isolated from Aspergillus terreus, displays in vivo and in vitro cytotoxicity. One approach focuses upon three transformations, two involving... 

Liu, S.-Y. and Bollag, J.M. Carbaryl decomposition to 1 -naphthyl carbamate by Aspergillus terreus, Pestic. Biochem. Physiol, l(2-3) 366-372, 1971. 

Low-Molecular Weight Xylanase Inducers. The response of cellulolytic fungi to low-molecular weight fragments of xylan and ceUulose confirmed the separate regulatory control of the formation of xylanases and ceUulases. Xylobiose [Xylp-p-(l- 4)-Xylp] was a specific inducer of xylanases in T. reesei (61) and Aspergillus terreus (67). Sophorose and otho glucobioses selectively induced the synthesis of... 

Vinci VA, Hoerner TD, Coffman AD, Schimmel TG Dabora RL, Kirpekar AC, Ruby CL, Stieber RW. (1991) Mutants of a lovastatin-hyper-producing Aspergillus terreus deficient in the production of sulochrin. J Indust Microbiol 8 113-120. 

Yoo ID, Cho KM, Lee CK, Km WG, Isoterreulactone A, a novel meroterpenoid with anti-acetylchoIinesterase activity produced hy Aspergillus terreus, BioorgMed Chem Lett 15 353-356, 2005. 

Lovastatin and mevastatin Lovastatin, (lS,3R,7S,8S,8aR)-l,2,3,7,8,8a-hexahydro-3, 7-dimethyl-8-[-[2R,4R]-[tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-l-naphthyl (S)-2-methylbutyrate (20.2.7) is isolated from Monascus rubber [17] mA Aspergillus terreus [18], as is mevastatin (lS,3R,7S,8S,8aR)-l,2,3,7,8, 8a-hexahydro-7-metliyl-8-[-(2R,4R)-[tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-l-naphthyl (S)-2-metliylbutyrate (20.2.8), which is isolated from Penicillium citrinum [19, 20] as well as from Penicillium brevicom-pactum [21]. 

Lovastatin and mevastatin are new-generation drugs that were introduced into medicine for treating hyperlipocholesterolemia, and they are unique compounds. Lovastatin is isolated from Aspergillus terreus mushrooms. Mevastatin is a chemically analogous compound that differs only in the absence of a methyl group at C3 of the naphthaline system, and it is isolated from Penicillium citrinum mushrooms. 

Interest in the total synthesis of the Aspergillus terreus derived quadrone fi06), an antitumor agent has been very intense. Success was first realized in Danishefsky s laboratory Once 601 was reached, its sidechain was elaborated and ring closure effected (Scheme LII). Condensation of 602 with 1-tert-butoxy-l-tcrt-butyl-dimethylsiloxyethylene in the presence of titanium tetrachloride and subsequent desilylation resulted in introduction of an angular acetic acid moiety. The two sidechains were next connected by intramolecular alkylation and the resulting keto add was subjected to selenenylation in order to produce 603. The a, P-unsaturated double bond was used to force enolization to the a position. Indeed, 604 was... 

Aspergillus terreus Merck Co Thom, and Lovalip/Riesel Monascus ruber van Ti em, Eumyc. 

SchemB 8 Reversible aldol addition reaction catalyzed by Aspergillus terreus KDGal aldolase.

A. M. Elshafei and O. M. Abdel-Fatah, Nonphosphorolytic pathway for D-galactonate catabolism in Aspergillus terreus, Enzyme Microb. Technol. 73 930 (1991). 

V. Delest and C. Aug6, The use of Aspergillus terreus extracts in the preparative synthesis of 2-keto-3-deoxy-ulosonic acids, Tetrahedron Asymm. 6 863 (1995). 

Itaconic acid Aspergillus terreus, Aspergillus itaconicus Synthetic fibre and resin manufacture copolymers (e.g. styrene-butadiene)... 

---