Immunosuppression cyclosporin

Cyclosporine -immunosuppressant -nephrotoxicity -hirsutism -hepatotoxicity -tremor -anxiety -hypertension... 

An order was written for 30 mg Cyclosporine (immunosuppressant) oral solution to be administered to a pediatric patient. However, for several days, the nurse administered 300 mg believing that the syringe was calibrated in mg not mL. The oral solution is available as 100 mg/mL. As the pharmacist reviewed the error, he noted that the syringes accompanying the medication were never designed for pediatrics. It is not possible to calculate any dose less than 50 mg. It is imderstandable how the nurse assumed that the 3 mark was for 30 mg since it is positioned between 2,5 and 3,5 (which are European style for the decimals 2.5 and 3.5). To harmonize products in the global market, the manufacturer chose to follow European convention for expressing numbers which uses commas and decimals in the reverse manner as in the United States. 

Levy GA. C2 monitoring strategy for optimising cyclosporin immunosuppression from the Neoral formulation. BioDrugs 2001 156 279-90. 

Kale, A.S., Ferry, G.D., Hawkins, E.R End-stage renal disease in a patient with cholesteryl ester storage disease following successful hver transplantation and cyclosporine immunosuppression. J. Pediatr. Gastroenterol. Nutrit. 1995 20 95-97... 

Wijdicks EF, Wiesner RH, Krom RA. Neurotoxicity in liver transplant recipients with cyclosporine immunosuppression. Neurology 1995 45(11) 1962. ... 

Taylor DO, Barr ML, Radovancevic B, Renlund DG, Mentzer RM Jr, Smart FW, Tolman DE, Frazier OH, Young JB, VanVeldhuisen P. A randomized, multicenter comparison of tacrohmus and cyclosporine immunosuppressive regimens in cardiac transplantation decreased hyperlipidemia and hypertension with tacrohmus. J Heart Lung Transplant 1999 18(4) 336-45. 

Lewis RM,Van Buren CT, Radovancevic B, Frazier OFi, Janney RP, Powers PL, Golden DL, Giannakis JG, MacrisMP, Kerman RH, et al. impact of long-term cyclosporine immunosuppressive therapy on native kidneys versus renal allografts serial renal function in heart and kidney transplant recipients. J Fleart Lung Transplant 1991 10 63-70. 

Thali M. Cyclosporins immunosuppressive drugs with anti-HIV-1 activity. Mol Med Today 1(6) 287-291, 1995. 

P. A randomized, multicenter comparison of tacrolimus and cyclosporine immunosuppressive regimens in cardiac transplantation decreased hyperlipidemia and hypertension with tacrolimus. J Heart Lung Transplant 1999 18 336-345. 

H. Cyclosporine immunosuppression mitigates immunologic risk factors in renal allotransplantation. Transplant. Proc. 15, 2469-2478 (1983). 

Cyanopuupehenol, 240 Ciratwpuupehenone, 249 Cyclosporin, immunosuppressive uses of, 2,41 Cytochalasins, 191 Cytotoxic agents... 

Grigg-Damberger MM, Costanzo-Nordin R, Kelly MA, Bahamon-Dussan JE, Silver M, Zucker MJ, Celesia GG. Phenytoin may compromise efficacy of cyclosporine immunosuppression in cardiac transplant patients. Epilepsia (1988) 29, 693. 

I m munosuppressive agents The incidence of cyclosporine-associated hypertension after renal, bone marrow, and cardiac transplantation varies between 30% and 100%. It is also common in patients with autoimmune disease and in patients with psoriasis treated with cyclosporine. Cyclosporine-induced hypertension is characterized by disturbance of the circadian rhythm, with the absence or reversal of the normal nocturnal fall in blood pressure. Hypertension usually decreases after the tvithdrawal or substitution of cyclosporine immunosuppression but may not remit completely... 

Cyclosporine Immunosuppressant cyclosporine is approved for use in transplant operations in the United States. 

Cyclosporine Immunosuppressant Sandimmune , Neoral Novartis Pharmaceuticals... 

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