Beauveria nivea

Some plant-derived drugs come from lower organisms, such as fungi (e.g., the antihyperlipidemic agent lovastatin from Aspergillus terreus and the immunosuppressant cyclosporin from Beauveria nivea) whereas others are obtained from higher plants (see Table 5.3 and Table 5.4). 

Fig 9. Some amino acid analogs incorporated into Cyclosporin A by Beauveria nivea (numbers in brackets indicate position of incorporation). 

Cyclosporine (cyclosporin A), a cyclic undecapeptide, is produced by the fungus Beauveria nivea. Cyclosporine is lipophilic and highly hydrophobic, and is formulated for clinical administration using castor oil or other strategies to ensure solubilization. 

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