From Plasmodium falciparum

A quite mysterious finding is the occasional positional replacement of ubiquitin-binding domains by ubiquitin-like domains. Parkin in Figure 12.7 is one example, another one is the UBX domain found instead of the UIMs in the ataxin-3 protein from Plasmodium falciparum [77]. There is no reason to assume that UbL domains might have a role in ubiquitin binding. A more likely explanation would be the requirement of these proteins to look like ubiquitin , irrespective of whether ubiquitin is part of the protein itself or rather bound to it non-covalently. 

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Singh N, Cheve G, Avery MA, McCurdy CR (2006) Comparative protein modeling of l-deoxy-D-xylulose-5-phosphate reductoi-somerase enzyme from Plasmodium falciparum a potential target for antimalarial drug discovery. J Chem Inf Model 46(3) 1360-1370... 

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Kandeel M, Kitade Y (2010) Substrate specificity and nucleotides binding properties of NM23H2/nucleoside diphosphate kinase homolog from Plasmodium falciparum. J Bioenerg Biomembr 42(5) 361-369... 

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Kruggel S, Lemcke T (2009) Generation and evaluation of a homology model of PfGSK-3. Arch Pharm (Weinheim) 342(6) 327-332 Bracchi-Ricard V, Barik S, Delvecchio C et al (2000) PfPK6, a novel cyclin-dependent kinase/mitogen-activated protein kinase-related protein kinase from Plasmodium falciparum. Biochem J 347(Pt l) 255-263... 

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Wernimont AK, Loppnau P, Crombet L et al. Crystal structure of PF10 0086, adenylate kinase from plasmodium falciparum. 

Robien MA, Bosch J, Hoi WG Crystal structure of nucleoside diphosphate kinase B from Plasmodium falciparum. 

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Dando, C., Schroeder, E. R., Hunsaker, L. A., Deck, L. M., Royer, R. E., Zhou, X., Parmley, S. F., and Vander Jagt, D. L. (2001). The kinetic properties and sensitivities to inhibitors of lactate dehydrogenases (LDH1 and LDH2) from Toxoplasma gondii Comparisons with pLDH from Plasmodium falciparum. Mol. Biochem. Parasitol. 118, 23-32. 

The Scientific American (www.sciam.com, 2001) reported a study at the National Institute of Allergy and Infectious Disease (United States) in which two mouse strains were genetically engineered to produce large quantities of a malarial parasite surface protein from Plasmodium falciparum. The malaria vaccine secreted in their milk was able to contain the disease in monkeys vaccinated with the same. This study has now been extrapolated to target livestock as the source animals. GTC is currently... 

Menting, J.G., Tilley, L., Deady, L.W., et al. (1997) The antimalarial drug, chloroquine, interacts with lactate dehydrogenase from Plasmodium falciparum. Mol. Biochem. Parasitol. 88, 215-224. 

Bai, T., Becker, M., Gupta, A., Strike, P., Murphy, V. J., Anders, R. F., and Batchelor, A. H. (2005). Structure of AMA1 from Plasmodium falciparum reveals a clustering of polymorphisms that surround a conserved hydrophobic pocket. Proc. Natl. Acad. Sci. USA 102,12736-12741. 

Mechanism-based inactivation of thioredoxin reductase from Plasmodium falciparum by Mannich bases. Implication for cytotoxicity. Biochemistry 42,13319-13330. 

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Menz, R. I., Cinquin, O., and Christopherson, R. I. (2002). The identification, cloning and functional expression of the gene encoding orotidine 5 -monophosphate (OMP) decarboxylase from Plasmodium falciparum. Ann. Trop. Med. Parasitol. 96,469 176. 

Perbandt, M., Burmeister, C., Walter, R. D., Betzel, C., and Liebau, E. (2004). Native and inhibited structure of a Mu class-related glutathione S-transferase from Plasmodium falciparum. J. Biol. Chem. 279,1336-1342. 

Vander Jagt, D. L., Baack, B. R., and Hunsaker, L. A. (1984). Purification and characterization of an aminopeptidase from Plasmodium falciparum. Mol. Biochem. Parasitol. 10, 45-54. 

Wu, Y., and Craig, A. (2006). Comparative proteomic analysis of metabolically labelled proteins from Plasmodium falciparum isolates with different adhesion properties. Malar. ]. 5,67. 

Xiao, H., Sinkovits, A. F., Bryksa, B. C., Ogawa, M., and Yada, R. Y. (2006). Recombinant expression and partial characterization of an active soluble histo-aspartic protease from Plasmodium falciparum. Protein Expr. Purif. 49, 88-94. 

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