Cyclin-dependent

Figure 13.30 Ribbon diagram of the structure of Src tyrosine kinase. The structure is divided in three units starting from the N-terminus an SH3 domain (green), an SH2 domain (blue), and a tyrosine kinase (orange) that is divided into two domains and has the same fold as the cyclin dependent kinase described in Chapter 6 (see Figure 6.16a). The linker region (red) between SH2 and the kinase is bound to SH3 in a polyproline helical conformation. A tyrosine residue in the carboxy tail of the kinase is phosphorylated and bound to SH2 in its phosphotyrosine-binding site. A disordered part of the activation segment in the kinase is dashed. (Adapted from W. Xu et al.. Nature 385 595-602, 1997.)...

A number of kinase structures have been determined in various catalytic states. For example, structures of the cyclin-dependent kinase, CDK2, in its inactive state and in a partially active state after cyclin binding have been discussed in Chapter 6. The most thoroughly studied kinase is the cyclic AMP-dependent protein kinase the structure of both the inactive and the active... 

Cell Cycle Control. Figure 1 Cell cycle regulation by Cyclin dependent kinases (CDKs). Different cyclins bound to different CDKs promote the transition from one cell cycle phase into another. CDK-dependent phosphorylation of Rb is required to release active E2F transcription factors, which promotes entry into S phase. 

Cyclin-Dependent Kinase 2 Cyclin-Dependent Kinase 4 Glycogen Synthetase Kinase p56 Lymphoid T Cell Tyrosine Kinase Protein Kinase CK2 (Casein Kinase II)... 

Figure 36-21. Schematic illustration of the points during the mammalian cell cycle during which the indicated cyclins and cyclin-dependent kinases are activated. The thickness of the various colored lines is indicative of the extent of activity.

Table 36-7. Cyclins and cyclin-dependent kinases involved in cell cycle progression.

Cyclin-dependent kinase 5 (cdk5) is a nonconventional cdk which plays important roles in the neuronal survival. Supernatants from HIV-infected macrophages... 

MTS1 Codes for p1 6 protein, a cyclin-dependent Involved in a wide range of cancers... 

Desai, D Gu, Y and Morgan, D. O. (1992). Activation of human cyclin-dependent kinases in vitro. Mol. Biol. Cell 3 571-582. 

Sebastian, B., Kakizuka, A., and Hunter, T. (1993). Cdc2M2 activation of cyclin-dependent kinase by dephosphorylation of threonine-14 and tyrosine-15 Proc. Natl. Acad. Sci. USA 90 3521-3524. 

Yasuda, H., Nakata, T., Masayuki, M., Honda, R., Nakamura, M Ninomija-Tsuji, J., Yamashita, M., Nagahama, Y., and Ohba, Y. (1992). Cyclin-dependent kinase 2 (cdk2) in the murine cdc2 kinase TS mutant Som. Cell Mol. Gen. 18 403-408. 

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