Paralysis flaccid

Pipera2ine causes flaccid paralysis of Jiscaris by blocking the worms abiUty to respond to acetylcholine, thus dislodging the worms from thek... 

Botulism is a disease caused by ingestion of foods contaminated with Clostridium botulinum (food-borne botulism) or, very rarely, by wound infection (wound botulism) or colonization of the intestinal tract with Clostridium botulinum (infant botulism). The toxins block the release of acetylcholine. Botulism is characterized by generalized muscular weakness, which first affects eye and throat muscles and later extends to all skeletal muscles. Flaccid paralysis can lead to respiratory failure. 

Anorexia, nausea, vomiting, mental depression, confusion, delayed or impaired thought processes, drowsiness, abdominal distention, decreased bowel sounds, paralytic ileus, muscle weakness or fatigue, flaccid paralysis, absent or diminished deep tendon reflexes, weak irregular pulse, paresthesias, leg cramps, ECG changes Hyperkalemia... 

Irritability, anxiety, listlessness, mental confusion, nausea, diarrhea, abdominal distress, gastrointestinal hyperactivity, paresthesias, weakness and heaviness of the legs, flaccid paralysis, hypotension, cardiac arrhythmias, ECG changes... 

Suberitine, a small protein from the sponge Suberites domcuncula, has a variety of actions. It is not very toxic but causes hemolysis in human erythrocytes, flaccid paralysis in crabs and depolarization of squid axon and abdominal nerve of crayfish. A variety of extracts from Porifera have been shown to be toxic to fish and generally have cytotoxic and hemolytic actions (62,63). As discussed previously, a variety of sponges exude substances that are toxic to fish. 

Clostridium botulinum 18-24 Canned fruits, vegetables, meats, honey, salsa, relish Weeks Acute Gl symptoms followed by symmetric, descending, flaccid paralysis death is possible Supportive (including mechanical ventilation) trivalent antitoxin... 

Delayed-action paralytic neurotoxins that block the release of acetylcholine causing a symmetric, descending flaccid paralysis of motor and autonomic nerves. Paralysis always begins with the cranial nerves. Toxins are obtained from an anaerobic bacteria (Clostridium botulinum). Toxin A is a white powder or crystalline solid that is readily soluble in water. It is stable for up to 7 days as an aqueous solution. All toxins are destroyed by heat and decompose when exposed to air for more than 12 h. 

Signs and Symptoms Symptoms include sudden onset of intense headache, fever, nausea, vomiting, and sensitivity to light (photophobia) followed by central nervous system abnormalities such as stupor, tremors, delirium, focal epilepsy and flaccid paralysis (especially in the shoulder), and coma. Recovery is prolonged. Sequelae may include paralysis of the upper extremities and back. 

Signs and Symptoms Most infections are asymptomatic or produce a nonspecific flulike illness. Symptoms include mild fever, headache, swollen lymph nodes, mental confusion, tremors, and flaccid paralysis. Liver and/or spleen may be enlarged. A maculopapular rash may be present on the trunk of the body. May progress to encephalitis and/or meningitis (meningoencephalitis) producing changes in mental status, seizures, and coma. 

Metachromatic leukodystrophy is due to a defect in arylsulfatase A (ASA). There are three major forms late infantile, juvenile and adult. The overall incidence is 1 40,000. In the late infantile and early juvenile forms, which comprise about 80% of patients, the initial symptoms involve the motor system, with falls, loss of ability to walk, flaccid paralysis, difficulty in swallowing, loss of speech, vision, seizures, decerebrate state and death 1-7 years after onset of symptoms. In the adolescent and... 

Severe — Seizures, dyspnea to apnea, loss of consciousness, flaccid paralysis. 

Symptoms Nerve agents exposures results in rhinorrhea, chest tightness, pinpoint pupils, shortness of breath, excessive salivation and sweating, nausea, vomiting, abdominal cramps, involuntary defecation and urination, muscle twitching, confusion, seizures, flaccid paralysis, coma, respiratory failure, and death. 

If meningitis is suspected in a patient with flaccid paralysis, medical personnel should use droplet precautions... 

The role of C2 toxin in disease is not clear because all C. botulinum strains that produce C2 toxin also synthesize extremely potent neurotoxins, the effector molecules of botulism. When Simpson compared the pharmacological properties of C. botulinum neurotoxin type Cl with C2 toxin in detail, it became obvious that C2 toxin does not cause the flaccid paralysis symptoms attributed to classic botulism. However, isolated C2 toxin is a potent enterotoxin that proves lethal in various animals 2 pmol of C2 toxin readily kill mice, rats, guinea pigs, and chickens within 1 h after application. For mice, the LD50 (i.v.) of C2 toxin is less than 50 ftnol. Ohishi and Odagiri also reported that C2 toxin causes necrotic, hemorrhagic lesions in the intestinal wall, whereas Simpson reported that C2 toxin elicits hypotension as well as fluid accumulation in the lungs. ... 

Muscle relaxants cause a flaccid paralysis of skeletal musculature by binding to motor endplate cholinoceptors, thus blocking neuromuscular transmission (p. 

M (Splayed hind limbs and flaccid paralysis of fore limbs in germ-free rats)... 

In other reports, rats and mice showed no effects at 20 ppm 7 hours/day for 90 days, but adverse effects were found following the 50 ppm regime. In a limited inhalation study, rabbits exposed at 206mg/m for 6 hours/day for 2 months developed unsteady gait and flaccid paralysis, whereas rabbits exposed at 17 mg/m for 5 months showed no evidence of toxic effects. ... 

Toxicology. Triorthocresyl phosphate (TOCP) causes peripheral neuropathy with flaccid paralysis of the distal muscles of the upper and lower extremities, followed in some cases by spastic paralysis. 

Adverse effects are usually the result of magnesium intoxication and include flushing sweating hypotension stupor depressed reflexes flaccid paralysis hypothermia circulatory collapse cardiac and CNS depression proceeding to respiratory paralysis (the most life-threatening effect). 

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