Peripheral neuropathy, caused

Miller B, Skupin A, Rubenfire M, Bigman O. Respiratory failure produced by severe procainamide intoxication in a patient with pre-existing peripheral neuropathy caused by amiodarone. Chest 1988 94(3) 663-5. 

Friedman MA, Resnick IS, Baer RL. Subepidermal vesicular dermatosis and sensory peripheral neuropathy caused by pyridoxine abuse. J Am Acad Dermatol 1986 14(5 Pt 2) 915-17. 

Heyman A, Pfeiffer JB, Willett RW, et al Peripheral neuropathy caused by arsenical intoxication. N Engl J Med 254 401-409, 1956 Jenkins RB Inorganic arsenic and the nervous system. Brain 89 479-498,1966 Krainer L, Black DAK, McGill RJ, et al Arsenical encephalopathy in Indian troops. 

Peripheral neuropathy causing muscle weakness and sensory loss... 

There is a similar high prevalence of peripheral neuropathy (34%) in the pediatric population infected with HIV (Araujo et al. 2000). The frequency of IDP in the HIV-infected population is unknown but is thought to be rare (Wulff et al. 2000). In an outpatient population of HIV positive patients, mononeuritis multiplex and lumbosacral polyradiculopathy were found in less than 1% of patients with AIDS (Fuller et al. 1993). HIV-associated autonomic nervous system dysfunction is also not uncommon as up to 66% of patients have papillary involvement and 15% have sympathetic and parasympathetic involvement causing orthostatic hypotension and respiratory sinus arrhythmia (Gluck et al. 2000). 

NRTls are structural analogues of the natural nucleotides that form the building blocks of RNA and DNA in human cells. Their use as part of HAART has dramatically modified the natural history of HIV infection. They, however, cause a range of drag- or tissue-specific toxicides zidovudine (AZT) causes myopathy zalcitabine (ddC), didanosine (ddl), and lamivudine (3TC) cause neuropathy stavudine (d4T) causes neuropathy or myopathy and lactic acidosis (Dalakas 2001). During phase 1 and 11 trials, the dose-limiting toxicity of didanosine, zalcitabine, and stavudine was identified as peripheral neuropathy (Dalakas 2001). 

Antibiotics have been studied based on the rationale that they may interrupt the inflammatory response directed against endogenous bacterial flora. Metronidazole and ciprofloxacin have been the two most widely-studied agents.32 Metronidazole may benefit some patients with pouchitis (inflammation of surgically-created intestinal pouches) and patients with CD who have had ileal resection or have perianal fistulas. Ciprofloxacin has shown some efficacy in refractory active CD. Both drugs may cause diarrhea, and long-term use of metronidazole is associated with the development of peripheral neuropathy. 

The cause of pruritus is unknown, although several mechanisms have been proposed. Vitamin A is known to accumulate in the skin and serum of patients with CKD, but a definite correlation with pruritus has not been established. Histamine may also play a role in the development of pruritus, which may be linked to mast cell proliferation in patients receiving hemodialysis. Hyperparathyroidism has also been suggested as a contributor to pruritus, despite the fact that serum PTH levels do not correlate with itching. Accumulation of divalent ions, specifically magnesium and aluminum, may also play a role in pruritus in patients with CKD. Other theories that have been proposed include inadequate dialysis, dry skin, peripheral neuropathy, and opiate accumulation.43... 

The lack of corroborative case reports, epidemiological data, or animal data (see next paragraph) makes the association between dermal exposure to mineral oil hydraulic fluids and peripheral neuropathy uncertain. Nonetheless, the presence of organophosphate esters, some of which are demonstrated neurotoxic agents, in most mineral oil hydraulic fluids (they often are added as anti-wear agents) suggests that they may play a causative role if such an association exists. 

Vinorelbine-vesicant avoid extravasation can cause peripheral neuropathy ... 

Cisplatin—vigorous hydration is required can be nephrotoxic and ototoxic can cause peripheral neuropathy hold or reduce for creatinine > 1.5... 

Oxaliplatin—can cause peripheral neuropathy which is generally reversible with cessation of treatment... 

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