Paralysis respiratory

Carbon disulfide, hydrogen sulfide, and sulfur dioxide should be handled carefully. Hydrogen sulfide in small concentrations can be metabolized, but in higher concentrations it quickly can cause death by respiratory paralysis. 

Health and Safety Factors. Carbonyl sulfide is dangerously poisonous, more so because it is practically odorless when pure. It is lethal to rats at 2900 ppm. Studies show an LD q (rat, ip) of 22.5 mg/kg. The mechanism of toxic action appears to iavolve breakdowa to hydrogea sulfide (36). It acts principally on the central nervous system with death resulting mainly from respiratory paralysis. Little is known regarding the health effects of subacute or chronic exposure to carbonyl sulfide a 400-p.g/m max level has been suggested until more data are available (37). Carbon oxysulfide has a reported inhalation toxicity in mice LD q (mouse) = 2900 ppm (37). 

Tendency to pulmonary oedema and eventually respiratory paralysis... 

Prolonged exposure may cause pulmonary oedema Systemic symptoms may occur in 0.5 to 1 hr Rapid collapse, respiratory paralysis imminent Immediately fatal... 

Neuromuscular blockade or respiratory paralysis may occur after administration of the aminoglycosides Therefore, it is extremely important that any symptoms of respiratory difficulty be reported immediately. If neuromuscular blockade occurs, it may be reversed by the administration of calcium salts but mechanical ventilation may be required. 

Stage IV is the stage of respiratory paralysis and is a rare and dangerous stage of anesthesia. At this stage, respiratory arrest and cessation of all vital signs may occur. 

Carbon monoxide cyanogen, hydrogen cyanide nitrites arsine aniline, dimethyl aniline, toluidine nitrobenzene hydrogen sulphide (causes respiratory paralysis by impairment of oxygen utilization in the central nervous system). 

These materials are hazardous through inhalation, penetration through broken skin, and ingestion. Symptoms include tingling, burning, numbness, drowsiness, incoherent speech, respiratory paralysis, and possibly cardiovascular collapse. 

Consequence prolonged respiratory paralysis on exposure to the drug Suxamethonium (succinylcholine) for muscle relaxation for anesthesia Slow acetylator phenotype, due to mutations in liver N-acetylase transferase,... 

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