Fillers food additives

The application (or Type II DMF) should include a detailed description of the complete container closure system for the bulk drug substance as well as a description of the specific container, closure, all liners, inner seal, and desiccant (if any), and a description of the composition of each component. A reference to the appropriate indirect food additive regulation is typically considered sufficient to establish the safety of the materials of construction. The tests, methods, and criteria for the acceptance and release of each packaging component should be provided. Stability studies to establish a retest period for bulk drug substance in the proposed container closure system should be conducted with fillers or desiccant packs in place (if used). Smaller versions that simulate the actual container closure system may be used. 

Starches - [FILLERS] (Vol 10) - [FOODS, NONCONVENTIONAL] (Vol 11) -dry-strength additives [PAPERMAKING ADDITIVES] (Vol 18) -as food additives [FOOD ADDITIVES] (Vol 11) -mpotash flotation [POTASSIUMCOMPOUNDS] (Vol 19) -for printing papers [PRINTING PROCESSES] (Vol 20)... 

Nanooxides such as fumed silica, titania, alumina, etc. (with spherical primary nanoparticles) are used as fillers for complex drugs, enterosorbents, vaccine adjuvants, food additives, etc.1,2 In general nonporous spherical nanoparticles can adsorb solutes in low amounts because the desolvation effect causes an... 

Properties White powder. D 2.9. Insoluble in water. Hazard Irritating dust. TLV 10 mg/m3. Use in foods restricted to 5% in baking powder, 2% in table salt. Use Absorbent, antacid, filler for paper and paper coatings, cosmetics, food additive (anticaking agent), manufacture of glass and Portland cement. See dicalcium silicate. 

Use Manufacture of kraft paper, paperboard, and glass filler in synthetic detergents sodium salts ceramic glazes processing textile fibers dyes tanning pharmaceuticals freezing mix laboratory reagent. food additive. 

Products and Uses Added to sea biscuits to prevent weevil infestation. Used in hair-setting lotions, personal care products, and cosmetic bases as a filler or additive, and for convalescent food. It is also an alcoholic beverage flavoring and a suspension agent for hair products and toiletries. 

Uses Paper sizing aids retention of filler and fiber aids pH control boiler water treatment food additive migrating to foods from paper/paperboard... 

Butylated hydroxytoluene is an additive used as an antioxidant in foods, such as packet cake mixes, potato crisps, salted peanuts, and dehydrated mashed potatoes. In March 1990 the Danish Product Register listed 440 products containing butylated hydroxytoluene the content was below 50 ppm in 66% of these products the main categories were paints/lacquers and hardeners for paints, glues, and fillers [19 ]. The safety of butylated hydroxytoluene, and of a number of other food additives, has been critically reviewed in a Danish report [20 ]. 

The resistance of plastic materials to attack by microorganisms (mold, fungi, and bacteria) depends not only on the chemical composition of the plastic, but also on the composition and amount of filler and additives as well as on relative ambient humidity. Additives serve as food for microorganisms, thus enabling attack on plastics that are inherently resistant. 

For food applications (- food additives), it is approved in many countries and it functions as a non-caloric filler, especially in dietary food, a dispersant in sugar gels, a fat substitute and an agent to control the formation of crystals in ice creams. Because m. is a relatively new material, further applications can be anticipated. 

National agencies concerned with regulating the materials for contact with food and drugs plus para-medical uses have long recognised the basic suitability of silicone rubber for such applications. The permitted silicone polymer types, fillers and additives are listed, for example in F.D.A. 21 CFR 177.2600 (USA) and Bundesgesundheitsblatt XV.Ill (Germany). 

Kaolinite. Kaolinite is a leaf-like or platy mineral and is the major constituent of kaolin or china clay. Kaolin is used in the manufacture of paper products, plastics, rubber, ceramics, and refractory materials, and as a filler in paints. It is also found in inks, adhesives, insecticides, medicines, food additives, bleach, absorbents, cements, fertilizers, cosmetics, crayons, pencils, detergents, paste, floor tiles, and textiles. 

Grade Selection Criteria Melt flow characteristics for injection moulding, extrusion and blow moulding. Filler/reinforcement additions, elastomer additions, food contact approvals, electrical properties. ... 

Before the twentieth century, most government controls were concerned not with drugs but with impure and adulterated foods. Medicines were thought to pose problems similar to those presented by foods. Efficacy was questioned in two respects adulteration of active medicines by addition of inert fillers and false claims made for the so-called patent (secret) medicines or nostrums. Indeed, much of the development of the science of pharmacy in the nineteenth century was standardizing and improving prescription drugs. 

Polymer-clay nanocomposites (PCN) are a class of hybrid materials composed of organic polymer matrices and organophilic clay fillers, introduced in late 1980s by the researchers of Toyota (Kawasumi, 2004). They observed an increase in mechanical and thermal properties of nylons with the addition of a small amount of nano-sized clays. This new and emerging class of pol miers has found several applications in the food and non-food sectors, such as in constmction, automobiles, aerospace, military, electronics, food packaging and coatings, because of its superior mechanical strength, heat and flame resistance and improved barrier properties (Ray et al., 2006). 

The particular absorber to be used in a given application depends on several factors. One important criterion is whether the absorber will strongly absorb that portion of the ultraviolet spectrum responsible for degradation of the plastic under consideration. Compatibility, volatility, thermal stability, and interactions with other additives and fillers are other items that must be considered. When used in food wrappings, Food and Drug Administration approval must be obtained. While one or more of these considerations may rule out a given stabilizer or influence llie choice of one class over another, the final selection must await the results of extensive accelerated and long-term tests. 

The manufacturers of tobacco products add fillers, flavor enhancers, preservatives, and other additives to make the product more desirable to consumers, especially low-tar brands. Each company s list of additives was a closely guarded trade secret until 1984, when the lists were submitted to the government. The public was barred from seeing the lists until 1994. The initial list contained 700 potential additives, of which 13 are not allowed in food. One additive, ammonia, may be included to boost the absorption of nicotine and enhance the addictive kick. Sweeteners and chocolate may help make cigarettes more attractive to children and first-time users. 

Casein is an insoluble protein found in milk. It is used to make adhesives and fillers, water-resistant coatings, and as an additive in some plastics and commercial food products like non-dairy creamers and soy cheese. The milk from cows, sheep, and goats has been used, alone or mixed with fillers, as gesso or as a tempera medium. Casein mixed with fillers such as sawdust or plant materials has been molded into various objects, such as buttons, knitting needles, button hooks, and jewelry. It has been used as an imitation of ivory under the commercial names erinoid and galalith. 

---