Fatty acid composition of serum lipids

Sovik, O., Mansson, J.E., Bjorke Monsen, A.L., Jellum, E. and Berge, R.K. (1998) Generalized peroxisomal disorder in male twins fatty acid composition of serum lipids and response to n-3 fatty acids. J. Inherit. Metab. Dis. 21 662-670. 

Miettinen TA, Naukkarinen V, Huttunen JK, Mattila S, Kumlin T. Fatty-acid composition of serum lipids predicts myocardial infarction. Br Med J. (Clin Res Ed), 1982,285 993-6. 

Vessby B, Tengblad S, Lithell H. Insulin sensitivity is related to the fatty acid composition of serum lipids and skeletal muscle phospholipids in 70-year-old men. 

Warensjo E, Riserus U, Vessby B. Fatty acid composition of serum lipids predicts the development of the metabolic syndrome in men. Diabetologia. 2005, 48 1999-2005. 

Fatty Acid Composition of Serum Lipids from Rats Fed Different Dietary Treatments for 84 d ... 

The Determination of the Fatty Acid Composition of Serum Lipids Separated by Thin-Layer Chromatography and a Comparison with Column Chromatography... 

Changes in Fatty Acid Composition of Serum Lipids... 

Table 3. Fatty acid composition of serum lipids in a-p-lipoproteinemia and sprue...

The fatty acid composition of serum and liver lipid fractions in the thyroxine, propylthiouracil, and control groups of rats is given in Table 3. Quantitatively, the most important change found by thyroxine administration was an increase of stearic acid and a decrease of linoleic acid in liver lipids. These results agree with those reported by Mitchel and Truchot (1962). Besides, the data in Table 3 show that arachidonic acid does not appear to be modified in the same way by thyroxine as linoleic acid, as it was reported previously (Mitchel and Truchot, 1962). 

An aliquot of the corresponding fraction of the samples was counted in a Packard Tricarb Scintillation counter. Other aliquots were esterified. The distribution of the radioactivity between the fatty acids was determined by gas liquid radiochromatography (Alaniz et al, 1976). The labeled methyl esters were identified by equivalent chain length determination and comparison with authentic standards. The fatty acid composition of serum, HTC cells and lipid fractions of culture cells was analyzed by gas liquid chromatography. The specific radioactivities for linoleic and arachidonic acids were calculated with those data after measuring the radioactivity in an aliquot in which the mass distribution of the fatty acids had previously been determined by gas liquid chromatography in the presence of an internal standard of eicosaenoic acid. 

The fatty acid composition of serum and different lipid fractions of HTC cells is shown in Table 1. The pattern is similar to that of the serum used in the preparation of the medium, except for changes in oleic, linoleic and a-linolenic acids. Whereas the relative amount of oleic acid was higher in the cells than in the... 

Uusitupa, M.I.J., Sarkkinen, E.S., 2002. Effect of a-linolenic acid-rich Camelina sativa oil on serum fatty acid composition and serum lipids in hypercholesterolemic subjects. Metab. Clin. Exp. 51,1253-1260. 

Wolk, A., Furuheim, M., and Vessby, B. (2001). Fatty acid composition of adipose tissue and serum lipids are valid biological markers of dairy fat intake in men. ]. Nutr. 131,828-833. 

A typical Western diet contains approximately 100-300 mg and 20-50 mg of plant sterol and plant stanol, respectively. The relationship between total dietary phytosterol content and the fatty acid composition of the diet decreases with increasing saturated fatty acids, whereas the total dietary phytosterol content increases with increasing PUFA (89). Fortification of lipid foods, such as margarine, with plant sterols will dramatically increase the daily intake of phytosterols and significantly lower serum cholesterol (90). The dietary consumption of large amounts of plant sterols will interfere with cholesterol absorption, thereby leading to an increased daily neutral steroid excretion. 

VanderJagt, D.J., Arndt, C.D., Okolo, S.N., Huang, Y.-S., Chuang, L.-T., and Glew, R.H. (2000) Fatty Acid Composition of the Milk Lipids of Fulani Women and the Serum of Their Exclusively Breast-Fed Infants, Early Hum. Dev. 60,73- 87. 

The first two metabolic studies compared the effects of HEAR and LEAR oils, when eaten as the sole source of added dietary fat, on serum lipid patterns (McDonald et al., 1974). Each study was divided into three phases a 9 day preliminary period when dietary fat was supplied by a mixture of fats typical of Canadian diets a 22 day experimental period when either LEAR oil and margarine or HEAR oil and margarine supplied the fat in the diet and an 8 day postexperimental period when the mixed fat again was eaten. The fatty acid compositions of the diets are shown in Table II. 

Seven male subjects were used in each of the 39 day metabolic studies. Twelve hour fasting blood samples were taken on days 1, 10, 18, 25, 32, and 39 of each study and samples of serum analyzed for cholesterol, lipid phosphorus, and the fatty acid composition of the phospholipids (McDonald eta/., 1974). 

Garaulet, M., Perez-Llamas, F., Perez-Ayala, M., Martinez, P., de Medina, F. S., Tebar, F. J., Zamora, S. (2001). Site-specific differences in the fatty acid composition of abdominal adipose tissue in an obese population from a Mediterranean area relation with dietary fatty acids, plasma lipid profile, serum insulin, and central obesity. Am J Clin Nutr, 74(5), 585-591. 

Fatty Acid Composition of Lipid Fractions in Diabetic Serum Lancet 1963-1 285-290 CA 58 ... 

D.R. Body, The lipid composition of adipose tissue. Progress in Lipid Research, 1988, 27, I, 39-60. K.N. Seidelin, Fatty acids composition of adipose tissue in humans. Implications for the dietary fat-serum cholesterol CHD issue, Progress in Lipid Research, 1995, 34,3, 199-217. 

Bragdon, j. H., and A. EIarmen The fatty acid composition of chylomicrons of chyle and serum following the ingestion of different oils. J. Lipid Res. 1, 167—170 (1960). 

The regulatory mechanism of cellular uptake of fatty acids appears to be limited and so the composition of the intracellular lipids is likely to reflect the availability of the fatty acids in the medium. This was shown for the CC9C10 hybridoma (Butler et al., 1997) and for BHK and CHO cells (Schmid et al., 1991). Thus, cells growing in serum-supplemented cultures are likely to attain a fatty acid composition reflecting that of serum, in which the predominant fatty acids are palmitic, stearic, oleic, and linoleic acids at a ratio 2 1 3 1, respectively. 

Fever accelerates lipid metabolism. The serum concentrations of cholesterol, nonesterified fatty acids, and the other lipids may decrease initially, but within a few days the free fatty acid concentration may increase. Fever is often associated with a respiratory alkalosis caused by hyperventilation. This pH increase causes a reduction of the plasma phosphate concentration, with an increased excretion of phosphate and other electrolytes. Serum iron and zinc concentrations decline with accumulation of both elements in the liver. The copper concentration increases because of increased production of ceruloplasmin by the liver. Some representative changes in serum composition induced by fever are listed in Table 17-12. 

Lipids with high levels of polyunsaturated fatty acids are considered desirable by many nutritionists because these lipids help to maintain low levels of blood cholesterol and favorable levels of serum high density lipoproteins. Many efforts are now directed at modification of the fatty acid composition in plants, especially the composition of seed oils (5). Genetic improvement of soybean oil is an especially desirable goal since the small amount of a-linolenic acid present in the oil causes flavor instability. 

The aim of the present study was to investigate the shortterm effects of DAG especially on the dynamics of postprandial serum lipids (8). A postprandial increase in remnant lipoproteins was also examined after oral loading of different types of oil emulsions, which contained either DAG or TAG of the same fatty acid composition, in a randomized, double-blind, crossover design. For the detection of changes in remnant lipoproteins after oral fat loading, we used measurements of cholesterol (RLP-C) and triacylglycerol (RLP-TG) in remnant-like lipoprotein particles (RLP) in the serum (9-11). 

Ristic-Medic D, Ristic V, Tepsic V, et al. Effect of soybean Leci-Vita product on serum lipids and fatty acid composition in patients with elevated serum cholesterol and triglyceride level. Nutr Res. 2003,23(4) 465-477. 

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