Expression analysis

Bioinformatics Gene Expression Analysis Microarray Technology Pharmacogenetics Proteomics... 

Gene Expression Analysis. Figure 1 Schematic representation of the experimental process of global gene expression analysis using Affymetrix GeneChip arrays. 

At present, the use of microarrays in pharmacology is especially established in the field of oncology by gene expression analysis with either tumour cell... 

Gene Expression Analysis. Figure 2 Contribution of gene expression profiling to the drug discovery process. 

In the context of gene expression analysis, gene products include proximal products, such as primary transcripts, intermediate products, such as mRNA, tRNA, and rRNA, and distal products including proteins and peptides. 

Gene Expression Analysis Gene Gun Gene Products Gene Promoter Gene Therapy Gene-therapy Vectors Gene Transfer... 

The ultimate goal of microarray-based expression analysis is to acquire a comprehension of the entire cellular process, in order to exploit and to standardize the multidi-menisional relations between genotype and phenotype. However, an increasingly important parameter, which has not yet been substantially taken into account, is the role of cellular translation. This means that mRNA expression data need to be correlated with the assortment of proteins actually present in the cell. One approach is based on the use of microarrays containing double-stranded DNA probes for the analysis of DNA-protein interaction and, thus, the detection and identification of DNA-binding proteins by means of fluorescence [130] or mass spectrometry analysis [131]. Moreover, substantial efforts are currently under way to develop protein, antibody, or even cell arrays, applicable to the cor-... 

Gunther EC, Stone DJ, Rothberg JM, Gerwien RW. A quantitative genomic expression analysis platform for multiplexed in vitro prediction of drug action. Pharmacogenomics J 2005 5 126-34. 

Swagell CD, Henly DC, Morris CP. Expression analysis of a human hepatic cell line in response to palmitate. Biochem Biophys Res Commun 2005 328 432-41. 

VII. Expression Analysis of the Tyrosinase Gene in Transgenic Mice.163... 

VII. EXPRESSION ANALYSIS OF THE TYROSINASE GENE IN TRANSGENIC MICE... 

Bird, D.M. and Wilson, M.A. (1994) DNA sequence and expression analysis of root-knot nematode elicited giant cell transcripts. Molecular Plant-Microbe Interactions 7, 419-424. 

Rosso, M.N., Favery, B., Piotte, C., Arthaud, L., de Boer, J.M., Hussey, R.S., Bakker, J., Baum, T.J. and Abad, P. (1999) Isolation of a cDNA encoding a beta-1,4-endoglucanase in the root-knot nematode Meloidogyne incognita and expression analysis during plant parasitism. Molecular Plantr-Microbe Interactions 12, 585-591. 

Phay, J. E., H. B. Hussain, and J. F. Moley. Cloning and expression analysis of a novel member of the facilitative glucose transporter family, SLC2A9 (GLUT9). Genomics 2000, 66, 217-220. 

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