Microarray analysis expression

Clarke PA, te Poele R, Wooster R, Workman P (2001) Gene expression microarray analysis in cancer biology, pharmacology, and drug development progress and potential. Biochem Pharmacol 62 1311-1336... 

The ultimate goal of microarray-based expression analysis is to acquire a comprehension of the entire cellular process, in order to exploit and to standardize the multidi-menisional relations between genotype and phenotype. However, an increasingly important parameter, which has not yet been substantially taken into account, is the role of cellular translation. This means that mRNA expression data need to be correlated with the assortment of proteins actually present in the cell. One approach is based on the use of microarrays containing double-stranded DNA probes for the analysis of DNA-protein interaction and, thus, the detection and identification of DNA-binding proteins by means of fluorescence [130] or mass spectrometry analysis [131]. Moreover, substantial efforts are currently under way to develop protein, antibody, or even cell arrays, applicable to the cor-... 

Chen, M.-L. Chen, C.-H. (2005b). Microarray analysis of differentially expressed genes in rat frontal cortex under chronic risperidone treatment. Neuropsychopharmacology, 30(2), 268-77. 

Hihara, Y., A. Kamei, M. Kanehisa, A. Kaplan, and M. Ikeuchi (2001). DNA microarray analysis of cyanobac-terial gene expression during acclimation to high light. Plant Cell 13(4) 793-806. 

Apart from SR-BI, SR-BII, CD36, and ABCA1, a microarray analysis of gene expression in human RPE reveals some additional lipid transporters that might potentially be involved in intracellular transport of carotenoids and/or their efflux from the RPE cells into the neural retina or out of the retina into the choroidal blood (van Soest et al., 2007). These include other ABC... 

Ichikawa JK et al. Interaction of Pseudomonas aeruginosa with epithelial cells identification of differentially regulated genes by expression microarray analysis of humans. Proc Natl Acad Sci USA 2000 97 9659-9664. 

Waring JF et al. Microarray analysis of hepatotoxins in vitro reveals a correlation between expression profiles and mechanisms of toxicity. Toxicol Lett 2001 120 359-368. 

Linton KM, Hey Y, Saunders E, et al. Acquisition of biologically relevant gene expression data by Affymetrix microarray analysis of archival formalin-fixed paraffin-embedded tumours. Br. J. Cancer 2008 98 1398-1402. 

Rogers, P. D. et al., Differential expression of genes encoding immunomodulatory proteins in response to amphotericin B in human mononuclear cells identified by cDNA microarray analysis, J. Antimicrob. Chemother., 50, 811, 2002. 

Gilbert RW, Costain WJ, Blanchard ME, Mullen K, Currie RW, et al. 2003. DNA microarray analysis of hippocampal gene expression measured 12 hours after hypoxia-ischemia in the mouse. J Cereb Blood Flow Metabol 23 1195. 

Jin K, Mao XO, Eshoo MW, Nagayama T, Minami M, et al. 2001. Microarray analysis of hippocampal gene expression in global cerebral ischemia. Ann Neurol 50 93. 

Matzilevich DA, Rail JM, Moore AN, Grill RJ, Dash PK. 2002. High-density microarray analysis of hippocampal gene expression following experimental brain injury. J Neurosci Res 67 646. 

Schena M, Shalon D, Heller R, Ghai A, Brown PO, et al. 1996. Parallel human genome analysis microarray-based expression monitoring of 1000 genes. Proc Natl Acad Sci USA 93 10614. 

Schmidt-Kastner R, Zhang B, Belayev L, Khoutorova L, Amin R, et al. 2002. DNA microarray analysis of cortical gene expression during early recirculation after focal brain ischemia in rat. Brain Res Mol Brain Res 108 81. 

Waring, J.F., Ciurlionis, R., Jolly, R.A., Heindel, M., and Ulrich, R.G. (2001) Microarray analysis of hepatotoxins in vitro reveals a correlation between gene expression profiles and mechanisms of toxicity. Toxicol. Lett. 120, 359-368. 

DNA microarrays offer the advantage of sensitivity, flexibility in the choice of genes for analysis, and power of analysis if combined with appropriate bioinformatics tools. Using DNA microarrays, the expression of thousands of genes can be measured simultaneously and in a high-throughput manner. 

The acute toxicity and oxidative effects of nano-scale Ti02 depend on the size of the nanoparticle (bulk Ti02 is positively nontoxic) and increase notably through illumination, as this leads to the formation of hydroxyl radicals [74], further indicating oxidative stress as a major candidate for the mechanism of action of NP toxicity. However, a recent microarray analysis of the transcriptome of zebrafish embryos treated with Ti02 NP showed no major increase of transcripts related to oxidative stress. Instead, significant effects were observed on expression of genes involved in circadian rhythm, kinase activity, vesicular transport, and immune response [75]. 

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