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Lentiviral vectors, gene therapy products

The lentiviral vectors have safety concerns similar to the retroviral vector-based gene therapy products (1) the production of a replication competent lentivirus (RCL) during manufacturing and (2) the potential for insertional mutagenesis, resulting in oncogene activation. One concern unique to the lentiviral vectors is the possibility that the vector can be mobilized in vivo,... [Pg.725]

Sinn P L, Sauter S L, McCray Jr P B (2005). Gene therapy progress and prospects Development of improved lentiviral and retroviral vectors—design, biosafety, and production. Gene Ther. 12 1089-1098. [Pg.1168]

Baekelandt, V., Eggermont, K., Michiels, M., Nuttin, B., and Debyser, Z. (2003). Optimized lentiviral vector production and purification procedure prevents immune response after transduction of mouse brain. Gene Therapy 10, 1933. [Pg.553]


See other pages where Lentiviral vectors, gene therapy products is mentioned: [Pg.745]    [Pg.269]    [Pg.344]    [Pg.58]    [Pg.64]    [Pg.559]    [Pg.566]    [Pg.210]    [Pg.535]   
See also in sourсe #XX -- [ Pg.724 , Pg.725 ]




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