Allele-specific differential expression analysis

The analysis of gene differential expression is complicated by the potentially subtle differences associated with alterations in a single allele as well as by variations between individuals that arise from environmental or physiological factors. To circumvent these analytic problems, a method, named allele-specific differential expression analysis, was developed to compare the relative expression levels of two alleles of the same gene within the same cellular sample. The studies of allele-specific expression revealed that differential expression is relatively common in the human population. 

Many other applications have been carried out using semi-quantitative primer extension based MALDI-TOF MS analysis with unknown analyte concentrations. One example involves the quantification of differential allele-specific expression. Medelian inheritance of allele-specific expression has been shown in humans (40). Allele-specific expression is of great importance for the identification of genetic components, which lead to population... 

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