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The next data to enter the scene were mRNA expression data (see Chapter 5 of volume 2). These data appeared in appreciable volumes in the mid nineties, first as ESTs [7] and then in various forms of micro arrays [8], It is fair to say that, today, from the application point of view a large part of scientific and industrial bioinformatics is preoccupied with analyzing these data. Transcending simple clustering approaches, the developed methods are now entering their second generation. Yet expression data analysis is still hampered by three issues ... 

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