Ethyl acetate nitrate

Piperidinium nitrate [6091-45-8] M 145.2, m 110 . Crystd from acetone/ethyl acetate. 

Cupric nitrate (3H2O) [10031-43-3 (3H2O) 3251-23-8 (anhydr)] M 241.6, m 114 , b 170 (dec), d 2.0. Crystd from weak aqueous HNO3 (0.5mL/g) by cooling from room temperature. The anhydrous salt can be prepared by dissolving copper metal in a 1 1 mixture of liquid NO2 and ethyl acetate and purified by sublimation [Evans et al. J Chem Soc, Faraday Trans 1 75 1023 1979], The hexahydrate dehydr to trihydrate at 26°, and the anhydrous salt sublimes between 150 and 225°, but melts at 255-256° and is deliquescent. 

Ammonium nitrate and other ammonium salts Any oxidizable substance, such as ethanol, methanol, glacial acetic acid, acetic anhydride, benzaldehyde, carbon disulphide, glycerol, ethylene glycol, ethyl acetate, methyl acetate or furfural Chlorates, perchlorates, permanganates... 

Attempts to prepare the anhydrous nitrate by dehydration always fail because of decomposition to a basic nitrate or to the oxide, and it was previously thought that Cu(N03)2 could not exist. In fact it can be obtained by dissolving copper metal in a solution of N2O4 in ethyl acetate to produce Cu(N03)2.N204, and then driving off the N2O4 by heating this at 85-100°C. The observation by C. C. Addison... 

Nonvolatile Nitrosamines In Tobacco. A method which we developed several years ago for the analysis of tobacco-specific nitrosamines (TSNA 31) involves extraction of tobacco with buffered ascorbic acid TpH 4.5) followed by partition with ethyl acetate, chromatographic clean-up on silica gel, and analysis by HPLC-TEA (Figure 9). Results obtained with this method for a large spectrum of tobacco products (Table IV), strongly support the concept that the levels of nitrate and alkaloids, and especially the methods for curing and fermentation, determine the yields of TSNA in tobacco products. Recent and as yet preliminary data from snuff analyses indicate that aerobic bacteria play a role in the formation of TSNA during air curing and fermentation. 

The addition of propylene also led to the increase of NO removal efficiency in a pulsed DBD in a mixture containing N2, 02, NO and 500 ppm C3H6 [30,35], Consequently, the energy cost for NO oxidation decreased from 42 to 25 eV/NO molecule [30], The authors also observed an increase in NO removal up to 30%. The major reaction products detected were carbon oxides, formaldehyde, acetaldehyde, propylene oxide, formic acid, ethyl acetate, methyl nitrate and nitromethane. 

A solution of 2-azido glycosyl nitrate 6 (2.5 mmol) and O-ethyl S-potassium dithiocarbonate 5 mmol) in acetonitrile (20 ml) was kept for 5 h at room temperature, diluted with dichloromethane (200ml), washed with water (30ml), dried (MgS04) and concentrated. Column chromatography of the residue (4 1 hexane-ethyl acetate, 0.3% triethylamine) gave the title compound in 97% yield. 

While nitramines are formed from the reaction of secondary amines with nitronium salts the success of the reaction depends on the basicity of the amine (Equation 5.11). Thus, amines of low to moderate basicity are A-nitrated in good yields. The nitration of more basic amines is slow and the nitrosamine is often observed as a significant by-product, a consequence of the partial reduction of the nitronium salt to the nitrosonium salt during the reaction. Increased reaction temperature is also found to increase the amount of nitrosamine formed. The amine substrate is usually used in excess to compensate for the release of the strong mineral acid formed during the reactions. Both nitronium tetrafluoroborate and the more soluble hexafluorophosphate are commonly used for A-nitrations. Solvents like acetonitrile, methylene chloride, nitromethane, dioxane, sulfolane, ethyl acetate and esters of phosphoric acid are commonly used. 

The efficient At-nitration of secondary amines has been achieved by transfer nitration with 4-chloro-5-methoxy-2-nitropyridazin-3-one, a reagent prepared from the nitration of the parent 4-chloro-5-methoxypyridazin-3-one with copper nitrate trihydrate in acetic anhydride. Reactions have been conducted in methylene chloride, ethyl acetate, acetonitrile and diethyl ether where yields of secondary nitramine are generally high. Homopiperazine is selectively nitrated to At-nitrohomopiperazine or At, At -dinitrohomopiperazine depending on the reaction stoichiometry. At-Nitration of primary amines or aromatic secondary amines is not achievable with this reagent. 

Olsen and co-workers used a solution of nitronium tetrafluoroborate in acetonitrile for the V-nitration of acetamides and urethanes at —30°C. The following nitramides were obtained by this method V-nitroacetamide (13 %), V-nitro-2-chloroacetamide (55 %), V-nitro-n-butylacetamide (40 %), V-nitrobenzamide (53 %), ethyl V-nitro-n-butylcarbamate (91 %) and V-nitrosuccinimide (43 %). The low yield of V-nitroacetamide, a primary nitramide, is attributed to competing hydrolysis due to the release of tetrafluoroboric acid as the reaction progresses. The scope of the reaction is improved by moving to more basic solvents like ethyl acetate, 1,4-dioxane and trimethyl phosphate. ... 

The nitration of both 4-methyl- and 4-chloro-2,6-dinitrotoluenes (66 and 67) with mixed acid in acetic acid at subambient temperature allows the isolation of the nitramines, (68) and (69), respectively. Thermolysis of (68) and (69) in refluxing methylene chloride yields the corresponding diazophenols, (70) and (71), respectively. Scilly and co-workers isolated 2-diazo-4,6-dinitrophenol (DINOL) (53) from the thermolysis of fV,2,3,5-tetranitroaniline (73) in ethyl acetate at 60 °C. 

Phenyl-l,2,4-triazoline-3,5-dione has been prepared by oxidizing 4-phenylurazole with lead dioxide,7 and with ammoni-acal silver nitrate followed by an ethereal solution of iodine.8 The yields are low for both methods. 4-Substituted triazoline-diones can also be made by oxidation of the corresponding urazole with fuming nitric acid9 or dinitrogen tetroxide.10 Oxidation by <-butyl hypochlorite in acetone solution has also been described 1112 it, however, yields an unstable product, even after sublimation. Either dioxane12 or ethyl acetate are preferred as solvents for the reaction, since the product is obtained in a stable form. The latter solvent is superior since... 

The nitrate salt prepared by this method is hydrated. It cannot be dehydrated fully without decomposition. Anhydrous CuNOs may be prepared by dissolving copper metal in a solution of dinitrogen tetroxide, N2O4, in ethyl acetate. Upon crystaUization, an N2O4 adduct of Cu(N03)2 that probably has the composition [NO [Cu(N03)3] is obtained. This adduct, on heating at 90°C, yields blue anhydrous copper(II) nitrate which can be sublimed in vacuum at 150°C and coUected. 

Inulin nitrate is insol in w, eth, ethyl and methyl ale, toluene and carbon tetrachloride, but dissolves in acetone, ether ale mixt, coned H2S04, ethyl acetate etc. It does not crystallize from solutions but forms a film... 

Sodium hydroxide. Sodium cyanide. Bromine, Sulfuric acid Sulfuric acid. Bromine, Sodium cyanide Acetone, Sulfuric acid. Bromine, Methylene chloride Biguanide, Ethanol, Perchloric acid. Ethyl acetate l,3-Dichloro-2-propanol, Trioxane, 1,2-Dichloroethane, Sulfuric acid, Sodium bicarbonate, Dimethylsulfoxide, Sodium azide. Methylene chloride Ammonium nitrate, Nitromethane Ammonium nitrate, Hydrazine Sodium nitrate, Sulfur, Charcoal Potassium nitrate, Sulfur, Charcoal Magnesium powder, Hexachlorethane, Naphthalene... 

Toluene, Sulfuric acid. Nitric acid Nitric acid. Sulfuric acid. Toluene Toluene, Sulfuric acid. Nitric acid. Methylene chloride Toluene, Sulfuric acid. Potassium nitrate. Methylene chloride Toluene, Sulfuric acid. Sodium nitrate. Methylene chloride Toluene, Sulfuric acid. Nitric acid. Premium unleaded gasoline Trifluoroacetic anhydride, Nitromethane, Ammonium nitrate, NIHT HCL, Ethyl acetate... 

Potassium nitrate, Sulfuric acid, 1,3,5-Trifluorobenzene, Methylene chloride, Hexane, Tert-butylamine, Trifluoroacetic acid, 1,2-Dichloroethane, 3-Amino-1,2,4-traizole, Glacial acetic acid, Sodium nitrite, Urea, Ethyl acetate, Dimethylformamide, Diethyl ether, Sodium sulfate, Methanol Ethanolamine, Diethyl ether, Ethyl chlorocarbonate, Sodium hydroxide, Magnesium sulfate, Nitric acid, Anhydrous ammonia... 

TNTC Trifluoroacetic anhydride, Nitromethane, Ammonium nitrate, NIHT HCL, Ethyl acetate Secondary high explosive ... 

Acetone, Sulfuric acid. Chlorine gas. Methylene chloride. Calcium chloride Acetone, Sulfuric acid. Chlorine gas. Chloroform, Calcium chloride Dimethoxy ethane, Nitrate trihydrate. Liquid hydrogen cyanide 3-Pyridol, Ethylmethylamine, Formaldehyde, Pyridine, Dimethylcarbamoyl chloride, Sodium carbonate, Chloroform, Sodium sulfate, 1,10-Dibromodecane, Acetone, Acetonitrile, Charcoal, Ethyl acetate... 

Ammonia gas, Carbon dioxide, Sodium chlorate Ammonia, Carbon dioxide. Sodium chlorate Hydrogen cyanide. Hydrocyanic acid. Prussic acid, Blausaure Hydrochloric acid. Methanol, ADNB, Methylene chloride. Nitric acid. Sodium bicarbonate. Magnesium sulfate 4,4-DNB, Methylene chloride. Magnesium sulfate. Sodium azide. Sodium hydroxide. Acetyl chloride. Ethyl acetate. Hexane TetranUine, Glacial acetic acid. Sodium azide Ammonium nitrate, TNT Sodium azide. Ammonia... 

Nitric acid. Urea, Sulfuric acid, Nitronium tetrafluoroborate. Anhydrous ammonia. Acetonitrile, Ethyl acetate. Chloroform Acetonitrile, Ammonium carbonate. Isopropyl alcohol, Nitronium tetrafluoroborate. Anhydrous ammonia. Diethyl ether. Acetone, Butanol, Ethyl acetate Ammonium nitrate, Diesel fuel... 

The octadiene 2 appears pure by proton magnetic resonance and elemental analysis. A thin-layer chromatogram [silica, developed with hexane-ethyl acetate (4 1), visualized with 5% ceric ammonium nitrate in 20% sulfuric acid and heating] shows a major spot at Rf =0.4 and a very small impurity at Rf = 0.7. The trace impurity may be removed by crystallization from hexane at —78°. The checkers found that a gas chromatogram (2% Silicone 0V-17... 

Fig. 92. Preparation of anhydrous copper nitrate a—setup for reacting metallic copper with nitrogen(IV) oxide in ethyl acetate 6—apparatus for distilling off the solvent...

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