Murine erythroleukemia cells

Hensold, J.O., Hunt, C.R., Calderwood, S.K., Housman, D.E., Kingston, R.E. (1990). DNA binding of heat shock factor to the heat shock element is insufficient for transcriptional activation in murine erythroleukemia cells. Mol. Cell Biol. 10, 1600-1608. 

One of the first HDAC inhibitors to be identified and characterized was sodium butyrate, where it was found to alter the histone acetylation state (Riggs et al, 1977), and further determined to inhibit HDAC activity both in vitro and in vivo (Candido et al, 1978). Almost a decade later trichostatin A (TSA), a fungistatic antibiotic, was found to induce murine erythroleukemia cell differentiation (Yoshida et al, 1987). To date, a wide range of molecules have been described that inhibit the activity of Class I and Class II HDAC enzymes, and with a few exceptions, can be divided into structural classes including (1) small-molecule hydroxamates, such as TSA, suberoylanilide hydroxamic acid (SAHA), scriptaid and oxamflatin (2) short-chain fatty-acids, such as sodium butyrate, sodium phenylbutyrate and valproic acid (VPA) (3) cyclic tetrapeptides, such as apicidin, trapoxin and the depsipeptide FK-228 and (4) benzamides, such as MS-275 and Cl-994 (for reviews see Remiszewski et al, 2002 Miller et al, 2003). Some of these molecules are represented in Fig. 4. 

Yoshida M, Nomura S, Beppu T (1987) Effects of trichostatins on differentiation of murine erythroleukemia cells. Cancer Res 47(14) 3688-3691 Yoshida M, Kijima M, Akita M, Beppu T (1990) Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A. J Biol Chem 265(28) 17174-17179 Yu ZX, Li SH, Nguyen HP, Li XJ (2002) Huntingtin inclusions do not deplete polyglutamine-containing transcription factors in HD mice. Hum Mol Genet 11(8) 905-914. 

Yoshida M, Nomura S, Beppu T. (1987) Effects of trichostatins on differentiation of murine erythroleukemia cells. Cancer Res 47 3688-3691. 

Slapak CA, Daniel JC, Levy SB (1990) Sequential emergence of distinct resistance phenotypes in murine erythroleukemia cells under adriamycin selection decreased anthracycline upt e precedes increase P-glycoprotein expression. Cancer Res 50 7895-7901... 

Rittenhouse, A. R., Vandorpe, D. H., Brugnara, C., and Alper, S. L. 1997. The antifungal imidazole clotrimazole and its major in vivo metabolite are potent blockers of the calcium-activated channel in murine erythroleukemia cells. 1. Membr. Biol. 157 177-191. 

Picard, V. Epsztejn, S. Santambrogio, P. Cabantchik, Z. 1. Beaumont, C. Role of ferritin in the control of the labile iron pool in murine erythroleukemia cells. J. Biol. Chem. 273 15382-15386 1998. 

Furst A, Brown E.H., Braunstein J.D., Schildkraut C.L. (1981). Alpha-globulin sequences are located in a region of early-replicating DNA in murine erythroleukemia cells. Proc. Natl. Acad. Sci. USA 78 1023-1027. 

Y. Jukuda, H. Fujita, S. Taketani, S. Sassa (1993). Dimethyl sulphoxide and haemin induce ferrochelatase mRMA by different mechanisms in murine erythroleukemia cells. Br. J. Haematol., 83, 480-484. 

Tsiftsoglou A S, Pappas I S, Vizirianakis I S (2003). The developmental program of murine erythroleukemia cells. Oncol. Res. 13 339-346. 

Hoffman J. Murine erythroleukemia cells resistant to periodate-oxidized adenosine have lowered levels of nucleoside transporter. Adv Exp Med Biol 1991 309A 443 46. 

Terada M, Nudel U, Fibach E, Rifkind RA, Marks PA (1978) Changes in DNA associated with induction of differentiation by dimethyl sulfoxide in murine erythroleukemia cells. Cancer Res 38 835-840... 

Sugiura M, Fram R, Munroe D, Kufe D (1984) DNA strand scission and ADP-ribosyltransferase activity during murine erythroleukemia cell differentiation. Dev Biol 104 484-488... 

Kinoshita, T., U. Sankawa, T. Takuma, K. Asahi, and N. Takahashi Induction of Differentiation in Murine Erythroleukemia Cells by Flavonoids. Chem. Pharm. Bull. (Japan), 33, 4109 (1985). 

Hsu B 1982 The influence of several anticancer agents on cell proliferation, differentiation and the cell cycle of murine erythroleukemia cells. Am J Chin Med 9 268-276... 

Shi WX, Chammas R, Varki NM, Powell L, Varki A (1996) Sialic acid 9-0-acetylation on murine erythroleukemia cells affects complement activation, binding to I-type lectins, and tissue homing. J Biol Chem 271 31526-31532... 

Gascoyne, P. Pethig, R. Burt, J. and Becker, F. (1993), Membrane changes accompanying the induced differentiation of Friend murine erythroleukemia cells studied by dielectrophoresis, Biochimica et biophysica acta. Biomembranes 1149(1), 119—126. 

A particularly useful system for studies of cell differentiation was found to be murine erythroleukemia cells (Marks and Rifkind, 1978). These proerythroblasts, transformed by the Friend virus complex, can be permanently grown in a cell culture. Exposure to dimethylsulphoxide or a variety of other inducers stimulates MEL cells to make a transition to the more advanced stages of erythroid maturation. An analysis of the differentiated state of individual cells, based on cloning cells in a semi-solid medium, has revealed (Housman et al., 1978) that an irreversible commitment to differentiation occurs as a discrete event at a given time after the application of the inducer. Removal of the inducer prior to this event returns a cell to its initial state, whereas its removal after this event leaves it in the differentiated state. 

Housman, D., Gusella, J., Geller, R., Levenson, R., and Weil, S., 1978, Differentiation of murine erythroleukemia cells The central role of the commitment event, "Cold Spring Harbor... 

Levenson, R., and Housman, D., 1979, Developmental program of murine erythroleukemia cells. Effect of the inhibition of protein synthesis, J. Cell Biol., 82 715. 

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