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Histones modification

A model called histone code theory includes more aspects of chromatin regulation which have been identified. The histone code theory predicts that histone acetylation and other posttranslational histone modifications serve as binding sites for regulatory proteins which mediate processes like gene transcription upon recruitment (see Fig. 2b) [3]. In this context histone modifications can be understood as... [Pg.592]

An important aspect of the histone code theory is that some modifications can be passed on during cell division. As a result histone modification patterns including histone acetylation serve as a means to store inheritable traits of an organism which are not DNA encoded. This kind of information is generally termed epigenetic information. [Pg.594]

Berger SL (2002) Histone modifications in transcriptional regulation. Curr Opin Genet Dev 12(2) 142-148... [Pg.108]

In the nuclei of all eukaryotic cells, DNA is tightly wrapped around an octamer of histone proteins and is compacted into a dense structure known as chromatin. In order to access the genetic information which is required in numerous essential cellular processes including DNA replication, gene expression and DNA repair, chromatin needs to be partially unwound. One important mechanism to regulate chromatin structure and thus to control the access of the genomic DNA is through histone modifications [1-6]. The histone octamer is composed of two copies of H2A, H2B, H3 and H4 core histone proteins. Their tails, that protrude out of the surface of the... [Pg.341]

Strahl BD, Allis CD (2000) The language of covalent histone modifications. Nature 403 41-45... [Pg.348]

Iizuka M, Smith MM (2003) Functional consequences of histone modifications. Curr Opin Genet Dev 13 154-160... [Pg.348]

Khan AU, Krishnamurthy S (2005) Histone modifications as key regulators of transcription. Front Biosci 10 866-872... [Pg.348]

Hake SB, Xiao A, Allis CD (2004) Linking the epigenetic language of covalent histone modifications to cancer. Br J Cancer 90 761-769... [Pg.348]

Holbert MA, Marmorstein R (2005) Structure and activity of enzymes that remove histone modifications. Curr Opin Struct Biol 15 673-680... [Pg.350]

The topic of histone modifications has been reviewed recently (Elgin and Weintraub, 1975 Dixon, 1976 Allffey, 1977 Isenberg, 1979), and no attempt will be made here to give a comprehensive review. However, we will present a brief summary of results which can be correlated with the structural role of histones. [Pg.44]

Regulating mono-ubiquitination of proteins by DUBs is important in histone modification where ubiquitination is thought to modulate chromatin structure and transcriptional activity. Normally, about 10% of the histone core octomers contain ubiquitinated histones and the ubiquitin is removed at mitosis by DUB activity. UBP8 has been demonstrated to regulate the ubiquitination of histone H2B, which is important in transcriptional activation of many genes [88]. [Pg.205]

Peterson CL, Laniel MA (2004) Histones and histone modifications. Curr Biol 14, R546-551 Pfaffle P, Gerlach V, Bunzel L, Jackson V (1990) In vitro evidence that transcription-induced stress causes nucleosome dissolution and regeneration. J Biol Chem 265 16830-16840 Poch O, Winsor B (1997) Who s who among the Saccharomyces cerevisiae actin-related proteins ... [Pg.27]

Strahl BD, Allis CD (2000) The language of covalent histone modifications. Nature 403 41-45 Suto RK, Clarkson MJ, Tremethick DJ, Luger K (2000) Crystal structure of a nucleosome core particle containing the variant histone H2A.Z. Nature Struct. Biol. 7 1121-1124 Swaminathan J, Baxter EM, Corces VG (2005) The role of histone H2Av variant replacement and histone H4 acetylation in the establishment of Drosophila heterochromatin. Genes Dev 19 65-76... [Pg.88]

Ueda K, Kinoshita Y, Xu ZJ, Ide N, Ono M, Akahori Y, Tanaka I, Inoue M (2000) Unusual core histones specifically expressed in male gametic cells of Lilium longiflorum. Chromosoma 108 491—500 Unal E, Arbel-Eden A, Sattler U, Shroff R, Lichten M, Haber JE, Koshland D (2004) DNA damage response pathway uses histone modification to assemble a double-strand break-specific cohesin domain. Mol Cell 16 991-1002... [Pg.110]

Sadri-VakiU G, Cha JH (2006) Mechanisms of Disease Histone modifications in Huntington s disease. Nature Qinical Practice Neurology 2(6) 330—338... [Pg.211]

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See also in sourсe #XX -- [ Pg.5 ]

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Histone

Histones histone modifications

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