Hormone deprivation

Whereas epidermal growth factor (EGF) enhances the radiosensitivity of human squamous ceU carcinoma cells in vitro (197), addition of EGF to hormone-deprived MCE-7 breast cancer cells prior to irradiation results ia iacreased radioresistance (198). An anti-EGE-receptor monoclonal antibody blocks the abiUty of EGE to enhance growth and radioresistance. Tumor cells, the growth of which is stimulated by EGE, appear to be protected those where growth is iohibited are sensitized (198). 

Hormone deprivation Deprivation of endogenous hormones by inhibition of biosynthesis of hormones or due to removal or inactivation of the hormone producing tissue... 

Hormone Deprivation - Inhibition of Steroid Hormone Biosynthesis... 

MERILLON, J.-M., OUELHAZI, L., DOIREAU, P., CHENIEUX, J.-C., RIDEAU, M., Metabolic changes and alkaloid production in habituated and non-habitualed cells of Catharanthus roseus grown in hormone-free medium. Comparing hormone-deprived non-habituated cells with habituated cells. J. Plant Physiol., 1989,134, 54-60. 

Compared with primary tumors, secondary testicular tumors are typically found in an older age group (older than 50 years of age). However, one third of the cases occur before age 40. Prostate carcinoma (50%) dominates the list of primary sources, in large part because of the prior practice of bilateral orchiectomy as part of the hormone deprivation therapy for PCa. Other primary sources, in descending order, include kidney, melanoma, and lung primaries. 

Tiredness and lethargy are the most common symptoms. Other effects include depression of the basal metabolic rate, appetite and cardiac output, Low-output heart failure may occur. The skin is dry. Thyroid hormone deprivation in early life results in irreversible mental retardation and dwarfism (cretinism), and to prevent this all newborn infants are screened and replacement therapy is given from birth. 

The functions of these different phases of sleep are not at all clear but chronic sleep deprivation does eventually lead to death. It seems to be the slow-wave component of sleep (SWS) that is vital and it is thought to serve a restorative purpose. This would be consistent with its greater occurrence during the early stages of the sleep cycle when hormone secretion supports anabolic metabolism. If subjects are wakened every time they enter a period of REM sleep (evidenced by the EEG) there appears to be no overt harmful effect on their behaviour. In fact, REM sleep deprivation has even been used, with some claims of success, as a treatment for minor depression. However, there is an unproven belief that REM sleep is important for memory consolidation. 

Nickel is considered essential to animals because it is present in the fetus or newborn, is homeostatically regulated, the metabolic pool of nickel is specifically influenced by hormonal substances or pathologic processes, certain metalloproteins contain nickel, and because nickel deficiency has been induced experimentally in certain species of birds and animals (NAS 1975 USPHS 1977 Kirchgessner and Schnegg 1980). In general, the nickel deficiency syndrome can be cured or prevented by trace amounts of nickel (NAS 1975). However, nickel administration may not be successful in reversing all abnormalities produced by nickel deprivation (USPHS 1977). 

The role of combined hormonal therapy, also referred to as maximal androgen deprivation or total androgen blockade, continues to be evaluated. 

In cell cultures deprived of hormones or in target organs of ovariectomized animals, ERs are found in a state known as native , characterized by their association with several proteins (Redeuilh et al. 1987). The best known are hsp90 and p59. 

So, drugs that block jSj-receptors lower the heart rate and blood pressure and hence are used in conditions when the heart itself is deprived of oxygen. They are routinely prescribed in patients with ischemic heart disease. In addition, j3-blockers prevent the release of renin, which is a hormone produced by the kidneys which leads to constriction of blood... 

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