Epidermal growth factor and

Carpenter, G. (1987). Receptors for epidermal growth factor and other polypeptide mitogens. Ann. Rev. Biochem. 56, 881—914. 

BP Hughes, JN Crofts, AM Auld, LC Read, GJ Barritt. (1987). Evidence that a pertussis-toxin-sensitive substrate is involved in the stimulation by epidermal growth factor and vasopressin of plasma-membrane Ca2+ inflow in hepatocytes. Biochem J 248 911-918. 

JD Johnson, JC Garrison. (1987). Epidermal growth factor and angiotensin II stimulates formation of inositol 1,4,5 and inositol 1,3,4-trisphosphate in hepatocytes. J Biol Chem 262 17285-17293. 

Xu B, Wiehle S, Roth JA, Cristiano RJ (1998) The contribution of poly-L-lysine, epidermal growth factor and streptavidin to EGF/PLL/DNA polyplex formation. Gene Ther... 

Ogiso H, Ishitani R, Nureki O, Fukai S, Yamanaka M, Kim J-H, Saito K, Sakamoto A, Inoue M, Shirouzu M, Yokoyama S (2002) Crystal structure of the complex of human epidermal growth factor and receptor extracellular domains. Cell 110 775-787... 

Epidermal growth factor and platelet-derived growth factor... 

Epidermal growth factor and related factors have a diverse range of actions in the nervous system 481... 

Central nervous system stem cells maintain an undifferentiated state and the capacity to self-renew in response to epidermal growth factor and fibroblast growth factor 507 Cell lineage studies reveal close associations between distinct neural cell types 508... 

Aulerich, R.J., S.J. Bursian, and A.C. Napolitano. 1988. Biological effects of epidermal growth factor and 2,3,7,8-tetrachlorodibenzo-p-dioxin on developmental parameters of neonatal mink. Arch. Environ. Toxicol. Chem. 17 27-31. 

Lee AV, Cui X, Oesterreich S (2002) Cross-talk among estrogen receptor, epidermal growth factor, and insulin-like growth factor signaling in breast cancer. Clin Cancer Res 7(12 Suppl) 4429s... 

According to current thinking, epithelial dysfunction, either intrinsic to asthma or caused by persistent inflammation, leads to epithelial release of profibrotic cytokines such as epidermal growth factor and TGF-P acting on fibroblasts and smooth muscle cells, disturbing the equilibrium... 

Birecree E, King LE, Nanney LB. 1991. Epidermal growth factor and its receptor in the developing human nervous system. Dev Brain Res 60 145-154. 

Shitara Y, Kato Y, Sugiyama Y. Effect of brefeldin A and lysosomotropic reagents on intracellular trafficking of epidermal growth factor and transferrin in Madin-Darby canine kidney epithelial cells. J Control Release 1998 55(1) 35 3. 

Fig. 6. Role of signal transduction pathways in phosphorylating H3 at Ser-10 and Ser-28. The Ras-MAPK (mitogen activated protein kinase) pathway is activated by EGF (epidermal growth factor) and TPA (12-0-tetradecanoylphorbol-13-acetate). UV-B activates both the Ras-MAPK pathway and the p38 kinase pathway (for more information about the signal transduction pathways see http // kinase, oci.utoronto.ca/signallingmap.html).

Bellacosa, A., Testa, J.R., Staal, S.P., Tsichdis, P.N. A role for akt in mediating the estrogenic functions of epidermal growth factor and insulin-like growth factor. Science 1991, 254, 274-277. 

Ebner, R., and R. Derynck. Epidermal growth factor and transforming growth factor-cc differential intracellular routing and processing of ligand-receptor complexes. Cell Regulation. 2 599-612.1991. 

Kanter P, Leister KJ, Tomei LD, Wenner PA, Wenner CE (1984) Epidermal growth factor and tumor promoters prevent DNA fragmentation by different mechanisms. Biochem Biophys Res Commun 118 392-399 Kariya K-I, Kawahara Y, Tsuda T (1987) Possible involvement of protein kinase C in platelet-derived growth factor-stimulated DNA synthesis in vascular smooth musde cells. Atherosderosis 83 251-255... 

Anthelmintic, antiprotozoal, anti-neoplastic, and antiviral agent Binds many proteins, i.e., cytokines. epidermal growth factor, and members of the FGF family inhibits dengue virus infec-tivity of host cells very long in vivo half-life, exhibits a wide range of toxic side effects 40-47... 

Dong M, Nio Y, Guo KJ, et al. Epidermal growth factor and its receptor as prognostic indicators in Chinese patients with pancreatic cancer. Anticancer Res 1998 18 4613-4619. 

Viloria-Petit AM, Rak J, Hung M-C, et al. Neutralizing antibodies against epidermal growth factor and ErbB-2/neu receptor tyrosine kinases downregulate vascular endothelial growth factor production by tumor cells in vitro and In vivo. Am J Pathol 1997 151 1523-1530. 

Dvorak, B., Fituch, C. C., Williams, C. S., Hurst, N. M., and Schanler, R. J. (2004). Concentrations of epidermal growth factor and transforming growth factor-alpha in preterm milk. Adv. Exp. Med. Biol. 554, 407--409. 

Hu P, Margolis B, Skolnik EY et al. Interaction of phosphatidylinositol 3-kinase-associated p85 with epidermal growth factor and platelet-derived growth factor receptors. Mo/ Cell Biol 1992 12 981-990. Li N, Batzer A, Daly R et al. Guanine-nucleotide-releasing factor hSosl binds to Grb2 and links receptor tyrosine kinases to Ras signalling. Nature 1993 363 85-88. 

May JV Schomberg DW (1989) The potential of epidermal growth factor and transforming growth factor-alpha to ovarian physiology. Semin Reprod Endocrinol, 7 1-6. 

Kuhn, H.G., Winkler, J., Kempermann, G., Thai, L.J., Gage, F.H. (1997). Epidermal growth factor and fibroblast growth factor-2 have different effects on neural progenitors in the adult rat brain. J Neurosci, 17, 5820-9. 

The insulin receptor is the prototype for a number of receptor enzymes with a similar structure and receptor Tyr kinase activity. The receptors for epidermal growth factor and platelet-derived growth factor, for example, have structural and sequence similarities to the insulin receptor, and both have a protein Tyr kinase activity that phosphorylates IRS-1. Many of these receptors dimerize after binding ligand the insulin receptor is already a dimer before insulin binds. The binding of adaptor proteins such as Grb2 to (P) Tyr residues is a common mechanism for promoting protein-protein interactions, a subject to which we return in Section 12.5. 

FIGURE 1 Structures of COX-1 and COX-2, (a) COX-1 with an NSAID inhibitor (flurbiprofen, orange) bound (PDB ID 3PGH). The enzyme consists of two identical monomers (gray and blue) each with three domains a membrane anchor consisting of four amphipathic helices a second domain that somewhat resembles a domain of the epidermal growth factor and the catalytic domain, which contains the cyclooxygenase and peroxidase activities, as well as the hydrophobic channel in which the substrate (arachidonate) binds. The heme that is part of the peroxidase active sites is shown in red ... 

Wong, R.W.C. and Guillard, L. (2004) The role of epidermal growth factor and its receptors in mammalian CNS. Cytokine and Growth Factor Reviews 15, 147-156. 

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