EINECS Substances

According to estimations by the European Commission, of the 100,000 EINECS substances aroimd 30,000 are manufactured or imported and marketed in the EU in annual volirmes in excess of one metric ton. Of this figure, aroimd 2500 substances have a production or import volume exceeding 1000 metric tons per annum. For these substances considerably more ecotoxicological and toxicological data are available than averaged out at all substances. ... 

Formamide is a registered substance, eg, in TSCA (75-12-7), EINECS (200-842-0), and MITI (2-681), and can, therefore, be produced in and imported into the United States, EEC, and Japan in compliance with the abovementioned acts. 

All eight PMBs are Hsted on the U.S. EPA s TSCA Inventory (May 1, 1994 ed.) and on the European Communities EINECS inventory (June 15, 1990). All but pentamethylbenzene are Hsted on the Canadian Domestic Substances List (DSL) (Apr. 6, 1994). Pentamethylbenzene is Hsted on the Canadian Nondomestic Substances List (NDSL) (Apt. 6, 1994) and as of July 1, 1994 was subject to New Substance Notification if manufactured in or imported into Canada. 

AH of the amyl alcohols are TSCA and EINECS (European Inventory of Existing Commercial Chemical Substances) registered. 

The LD q for sodium bromide taken orally by rats is 3.5 g/kg body weight, and the TD q orally in rats is 720 mg/kg (8). RTECS Hsts data on reproductive effects in male and female rats. Sodium bromide is Hsted in the TSCA Inventory, the Canadian Domestic Substances Hst (DSL), the European Inventory of Existing Commercial Chemical Substances (EINECS), the Japanese Existing and New Chemical Substances (ENCS), and the Korean Existing Chemicals Hst (ECL). It is not regulated by the U.S. Department of Transportation. 

Poly(vinyl chloride) is Hsted on the TSCA inventory and the Canadian Domestic Substances List (DSL) as ethene, chloro-, homopolymer [9002-86-2]. Because polymers do not appear on the European Community Commercial Chemical Substances listing or EINECS, poly(vinyl chloride) is listed through its monomer, vinyl chloride [75-01-4]. In the United States, poly(vinyl chloride) is an EPA hazardous air pollutant under the Clean Air Act Section 112 (40 CER 61) and is covered under the New Jersey Community Right-to-Know Survey N.J. Environmental Hazardous Substances (EHS) List as "chloroethylene, polymer" with a reporting threshold of 225 kg (500 lb). 

Substances listed on die European Inventory of Exisdng Chemical Substances (EINECS). 

EINECS The European inventory of existing commercial chemical substances... 

European dynamic filter, 11 384 European Inventory of Existing Chemical Substances (EINECS), 26 901 European Molecular Biology Laboratory (EMBL) database, 12 512 European patent, 18 198 European Patent Classification (ECLA) scheme, 18 209, 230 European Patent Convention (EPC), 18 189, 191... 

Existing chemical substances do not have to be notified. These are defined as those listed on the European Inventory of Existing Chemical Substances (EINECS) (a. 1), a list of approximately 100,000 substances reported as being supplied in the EU during the reporting period of 1 January 1971 to 18 September 1981 (389, 394). Also the DSD does not apply to medicinal products, cosmetic products, wastes, foodstuffs, pesticides, biocides and radioactive substances. 

If a substance is not listed in EINECS and not included in the scope of the DSD, it is considered to be new and a prospective EU supplier has to notify it, unless an exemption applies, as discussed below. It is also possible that the substance has already been notified and there is an obligation to make a data-sharing enquiry (DSE) to find out it there is another notification already in place. The aim of the exercise is to reach an agreement to share the notification studies, in the interests of animal welfare. Some countries make data sharing mandatory for animal studies. 

The EU Existing Chemicals Regulation (ECR) (390) applied to all EU manufacturers or importers of existing chemical substances listed in EINECS. Each manufacturer or importer had to report the administrative and technical information and the available data on hazardous properties for substances supplied at above 1000 tonnes per annum dining the period 23 March 1990 to 23 March 1994. Only administrative and technical information had to be reported for substances supplied at 10 to 1,000 tonnes per annum The information has been collated into a EU database, and anon-confidential version is available called the International Uniform Chemicals Information Database (a.4). 

EINECS European Inventory of Existing Chemical Substances POP Persistent organic pollutant... 

A conflict clearly exists between permanent confidentiality, available under the system of U.S. laws, and the eventual disclosure of identities of specialized chemical substances which had heretofore been undisclosed, but which are now affected by EINECS or by EEC s premarketing notification system. The rules are different the assumptions regarding disclosure are different. Perhaps the best solution a lawyer could offer is that member states should be willing to adjudicate individual cases of specific confidentiality needs. Inventories of existing substances are rules, adopted prospectively to announce to the world both the existence of a material and its regulatory status. Those rules can operate to accommodate both public and private needs. 

In terms of chemicals legislation substances are elements or compounds in the natural state or obtained by any production process, including any additive necessary to preserve the stability of the products and any impurity from the process used. A substance (as determined by its CAS or EINECS number) may be a desired combination of products from a chemical reaction or a distillation fraction (in refinery products) and/or may contain urrdesired impurities. This means that the same substance may indeed exhibit differerrt properties. 

The inventory of substances on the EU market is just over 100,000 substances listed in the EINECS register (European Inventory of Existing Chemical Substances ) and ELINCS register (Eiuopean List of Notified New Substances ). 

In accordance with EEC ordinance no. 793/93 (existing substances ordinance) dated 1993, manufacturers and importers have to submit the available data for every substance listed in EINECS to the European Chemicals Bureau (ECB), if their production volume or import volume was in excess of 10 t/a in a predefined reference period. All in all, the industry has submitted data covering the basic data set of European chemicals legislation in only 14% of cases for high-volume existing substances (2500 substances > 1000 t/a) . Details concerning exposure were even more patchy. 

The 6th amendment also introduced a notification system for new substances (Section 2.4.1.5) and, consequently, required the establishment of the list of existing substances called EINECS (Section 2.4.1.4). 

Existing substances are substances deemed to be on the EU Market between 1 January 1971 and 18 September 1981 and listed in EINECS, the European INventory of Existing Commercial Chemical Substances (EU 2006j, ECB 2006). The substances placed on the market for the first time after this target date are new (Section 2.4.1.5). 

EINECS is a closed list containing 100,106 entries and counts for about 99% of the chemicals volume on the market. EINECS include chemical substances produced from natural products by chemical modifications or purification, such as metals, minerals, cement, refined oil, and gas substances produced from animals and plants active substances of pesticides, medicaments, fertilizers, and cosmetic products food additives a few natural polymers and some waste and by-products. They can be mixtures of different chemicals occurring namrally or as an unintentional result of the production process. 

Existing substances do not include Synthetic polymers (which are registered in EINECS under their building block monomers) medical, cosmetic, and pesticide preparations as intentional mixtures food feedstuffs alloys, such as stainless steel (but individual components of alloys are included) and most naturally occurring raw materials, including coal and most ores. 

For existing substances, the data collection consists of three phases. The ESR was initially concerned with the so-called HPVCs (High Production Volume Chemicals). HPVCs are those substances, which are covered by the data collection phases I and II of the ESR, i.e., those substances which have been imported or produced in quantities exceeding 1000 tons per year and produced/imported between March 23 1990 and March 23 1994. During phase I, 1884 substances were extracted from EINECS - referred to as the HPVC list these substances are listed in Annex I of ESR. The total list of substances reported under phases I and II of the Regulation is now referred to as the EU-HPVC list. 

New substances are substances, which were not on the EU Market on or before 18 September 1981 and therefore not listed in EINECS (ECB 2006, EU 2006J). 

EC (2002) European inventory of existing commercial chemical substances (EINECS). http //esis.jrc.ec.europa.eu/index. php PGM = ein. Accessed 29 Oct 2011... 

---