High-production volume chemicals

The European Commission (EC) has sponsored four reports that evaluate a set of 553 substances selected by experts and stakeholders for assessment for endocrine disruption. Each report addresses a subset of the total set based on priorities such as whether the chemicals are persistent, bioaccumulating or High Production Volume chemicals and/or whether or not there is already regulatory control of the chemical. 

HPVIS provides complete and easy access to technical health and environmental effect information on chemicals that are manufactured or imported to US in volumes greater than IMM lbs per year. Information in this database are submitted through HPV Challenge Program. HPVIS allows users to search for summary information, test plans, and new data on high production volume chemicals as they are developed. 

HPVCs (High Production Volume Chemicals) and LPVCs (Low Production Volume Chemicals), including EU Producers/Importers lists... 

Institute for Health and Consumer Protection - European Chemicals Bureau Pubhc Availability of Data on EU High Production Volume Chemicals, 1999. These substances are documented in the lUCLID database (International Uniform Chemical Information Database). 

For existing substances, the data collection consists of three phases. The ESR was initially concerned with the so-called HPVCs (High Production Volume Chemicals). HPVCs are those substances, which are covered by the data collection phases I and II of the ESR, i.e., those substances which have been imported or produced in quantities exceeding 1000 tons per year and produced/imported between March 23 1990 and March 23 1994. During phase I, 1884 substances were extracted from EINECS - referred to as the HPVC list these substances are listed in Annex I of ESR. The total list of substances reported under phases I and II of the Regulation is now referred to as the EU-HPVC list. 

In the EU, 141 of existing high production volume chemical substances have been prioritized for an in-depth risk assessment, see Section 2.4.1.4 for details. 

Uses. A high-production-volume chemical used in manufacture of epoxy-phenolic resins (protective linings for food and beverage cans) monomer for polycarbonate resins (used in food contact materials such as returnable beverage bottles, infant feeding bottles, plates, and mugs) antioxidant in PVC plastics inhibitor of end polymerization in PVC plastics... 

United Nations Environment Programme Chemicals (2000) OECD High Production Volume Chemicals Programme. Phase 3. SIDS (Screening Information Data Set), initial assessment report [http //irptc.unep.ch], Geneva... 

Hansen, B. and K. van Leeuwen. 1995. US-EU-Japan Collaborative Project on Fate and Effects Predictions for High Production Volume Chemicals an Overview. Report to the HAAB, January 1995. HAAB0195.DOC, October 1995. 

Bol J, Verhaar HJM, van Leeuwen CJ, Hermens JLM. 1993. Predictions of the aquatic toxicity of high-production-volume-chemicals. Part A introduction and methodology. The Hague (The Netherlands) Netherlands Ministry of Housing Spatial Planning and the Environment (VROM). 

Organisation for Economic Co-operation and Development [OECD]. N.d.-a. Description of OECD work on investigation of high production volume chemicals. http //www. oecd.org/document/21/0,2340,en 2649 34379 1939669 l l l l,00.html (accessed January 8, 2008). 

Limited preliminary information is available on reproductive and developmental toxicity from the screening information data sets for high production volume chemicals. 

Rorije, E., Muller, M., and Peijnenburg, W.J.G.M., Prediction of Environmental Degradation Rates for High Production Volume Chemicals (HPVC) using Quantitative Structure-Activity Relationships, Report No. 719101030, National Institute of Public Health and Environmental Protection, Bilthoven, The Netherlands, 1997. 

Mononitrophenols exist in three isomeric forms 2-nitrophenol (or ortho- or o-), 3-nitrophenol (or meta- or m-), and 4-nitrophenol (or para- or p-). In this document, the two high-production- volume chemicals, 2-nitrophenol and 4-nitrophenol will be discussed. Data pertaining to the chemical identities of these two nitrophenols are listed in Table 3-1. 

Two screening reproduction toxicity study protocols were prepared by the OECD for initial evaluation of existing chemicals, especially of existing high production volume chemicals but also for initial exploratory tests at an early stage of assessing the toxicological properties of new chemicals or chemicals of concern. 

Harbers JV, Huijbregts MAJ, Posthuma L, Van de Meent D. 2006. Estimating the impact of high-production-volume chemicals on remote ecosystems by toxic pressure calculation. Environ Sci Technol 40 1573-1580. 

The high production volume chemical, 4-chloro-2-methylphenol, XVI was photolysed in distilled and natural waters and aqueous solutions of soil-extracted humic substances (Ranker, Spain) under various irradiation conditions with monochromatic light at 280 nm, using polychromatic lamps emitting between 300 and 450 nm, and in natural sunlight (June, Clermont-Ferrand, France) [78,79]. 

Allanou, R., Hansen, B. G. and van der Bilt, Y. (1999) Public availability of data on EU high production volume chemicals. Ispra European Commission Joint Research Centre, Institute for Health and Consumer Protection, European Chemical Bureau. 

EDF (2007b) High Hopes, Low Marks. A Final Report Card on the High Production Volume Chemical Challenge. Washington, DC Environmental Defense Fund (EDF). 

Manual for Investigation ofHPV Chemicals, Description of OECD Work on Investigation of High Production Volume Chemicals, OECD, Paris, France, 2005. http //www.oecd. org/document/21/0,2340, en 2649 34379 1 939669 l l l l,00.html. 

Manual for Investigation of HPV Chemicals Description of OECD Work on Investigation of High Production Volume Chemicals, 2005, p.3. 

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