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Effect on response

The most important hardware items appeared to be the detectors themselves. The gas detection system gave frequent spurious alarms, and on both platforms the ultraviolet (UV) fire detectors were also prone to spurious activation from distant hot work for example, and had a limited ability to detect real fires. The tmreliability of these systems had a general effect on response time and would, overall, lengthen the time to respond. The second aspect which was related to hardware was fimction and performance testing of the emergency blowdown systems. It is critical that the workers believe the systems will work when required, and this can only be achieved by occasional use or at least fimction testing. [Pg.339]

Homanics, G. E., Ferguson, C., Quinlan, J. J., et al. (1997) Gene knockout of the alpha6 subunit of the gamma-aminobutyric acid type A receptor lack of effect on responses to ethanol, pentobarbital, and general anesthetics. Mol. Pharmacol. 51, 588-596. [Pg.93]

A similar effect is observed when increased concentrations of the Ab-ALP conjugate were utilized to study the time-dependent effect on response, while keeping other reagents and their incubations constant. At any fixed time interval, the response observed (Figure 19.3) was found to be directly dependent on the protein concentration of the Ab-ALP conjugate. [Pg.472]

TNFRSFIA -609, May affect ligand binding No effect on response to 70... [Pg.429]

HLA DR, DQ alleles May affect response to TNF blockade and increase susceptibihty to and severity of RA because of close proximity to TNF locus No effect on response to INF 69 Specific individual HLA 70 DRB1 alleles and haplotype markers of increased response to ETN... [Pg.430]

MHC class I chain-related gene A transmembrane polymorphism As above No effect on response to INF 69... [Pg.430]

The second area of progressive development will be in the area of very specialized data collection mediums. We foresee a major extension in the area of direct data input using interactive video terminals built within the sensory evaluation booths. Although this will take a fairly extensive development in the area of software, the gains to be reaped by the development will far exceed the development costs itself. A large area of research has yet to be conducted concerning the application of microcomputers in sensory analysis as a data collection tool. Studies of inherent bias, effects on response freedom etc. will have to be undertaken in order to properly evaluate the computer as a data acquisition tool. Biases based on the way the software... [Pg.8]

Expression of selected elements of the 5-FU metabolic pathway is predictive of response to 5-FU based chemotherapy regimens. High levels of TS, TP, and DPD are independent predictors of decreased response vice versa, lower levels of TS, TP, and DPD correlate with higher sensitivity to 5-FU. High expression levels of one of these genes, even in the presence of down-regulation of the other two, has an adverse effect on response to 5-FU. [Pg.167]

B. Effect on Response to Interleukin-2, Antigen-Driven Proliferation... [Pg.247]

Peripheral autonomic nervous system Dog (anesthetized) Parenteral Effects on response to known drugs and electrical stimulation of central and peripheral autonomic nerves... [Pg.92]

Drawing conclusions after processing experimental outcomes may be very complex depending on the number of factors, on the type of experiment or level of research objective (screening of factors by significance of their effect on response, mathematical modeling and optimization of the process). Complexity of obtained models and... [Pg.313]

According to values of regression coefficients it is evident that factor X2 has the smallest effect on response. The existence of triple interaction makes transformation of the regression model into canonical form difficult, which, in turn, makes a detailed study of the response surface and establishing conditions for maximal response impossible. [Pg.460]

The adenosine modulation of synaptic transmission exceeds the simple direct control of neurotransmitter release. Adenosine may have a permissive effect on responses to other presynaptic modulators, may regulate the rate of desensitization of other presynaptic receptors, or prevent an excessive influence of inhibitory receptors. In this respect it is often viewed as a modulator of modulators involved in the fine-tuning of neurotransmitter release. [Pg.340]

It should be pointed out that all these effects on response kinetics of the EAG could be caused by malfunction in a subset of ORNs rather than represent changes in kinetics of the receptor potentials. Since EAG and EPG represent summations of such potentials, and ORNs differ greatly in their temporal response dynamics, a deletion of a subset of ORNs with a minor contribution to final amplitude could change the steepness of rise or fall of the EAG. [Pg.675]

Fig. 6. A multistate model of receptor function with three states. The receptor population consists of an inactive receptor conformation (R) in equilibrium with two (or more) active receptor conformations (R and R ). Each active conformation can differentially activate effector mechanisms, leading to response 1 or response2 in the absence of an agonist. Two isomerization constants (L and M) define the propensity of the receptor to adopt an active conformation in the absence of a ligand. Agonists can differentially stabilize R vs R depending on the value of the equilibrium dissociation constants KA and KA relative to KA. Inverse agonists can also have differential effects on response 1 vs. response2 depending upon the relative values of L and M and of the affinity constants. Additional active states with additional isomerization and affinity constants can be added. Adapted from Leff et al. (86) and Berg et al. (22). Fig. 6. A multistate model of receptor function with three states. The receptor population consists of an inactive receptor conformation (R) in equilibrium with two (or more) active receptor conformations (R and R ). Each active conformation can differentially activate effector mechanisms, leading to response 1 or response2 in the absence of an agonist. Two isomerization constants (L and M) define the propensity of the receptor to adopt an active conformation in the absence of a ligand. Agonists can differentially stabilize R vs R depending on the value of the equilibrium dissociation constants KA and KA relative to KA. Inverse agonists can also have differential effects on response 1 vs. response2 depending upon the relative values of L and M and of the affinity constants. Additional active states with additional isomerization and affinity constants can be added. Adapted from Leff et al. (86) and Berg et al. (22).
Acetylcholine sensors construction, 115 schematic representation, 120f substrate concentration, effect on response, 121/... [Pg.324]


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See also in sourсe #XX -- [ Pg.337 ]




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Response Effectiveness

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