Receptor potentials

These are a subset of sensory neurons having their cell bodies (small to medium size) in dorsal root and in cranial nerve ganglia and possessing nonmyelinated (C-type) or thinly myelinated (A-delta type) fibres. This subset of neurons express transient receptor potential vanilloid type 1 (TRPV1, or vanilloid, or capsaicin receptor) that is excited by capsaicin, the pungent ingredient of chilli. These neurons have been classified as polymodal nociceptors because they can be excited by various noxious stimuli. 

Abu J, Batuwangala M, Herbert K et al (2005) Retinoic acid and retinoid receptors potential chemopreventive and therapeutic role in cervical cancer. Lancet Oncol 6 712-720... 

The founding member of the TRP channel family, TRP, was identified as the product of a gene locus, which was referred to a transient receptor potential (TRP), because TRP mutant flies display a defect in light induced Ca2+ influx. 

A superfamily of cation channels conserved in mammals, flies, worms and yeast. The various TRP-proteins bear-sequence and predicted structural similarities to the founding member of this superfamily, transient receptor-potential (TRP), a light activated cation channel in the Dmsophila photoreceptor. 

Transgenic Animal Models Transient Receptor Potential Transition State Translation Inhibitors Translocon... 

Fig. 1.—Diagrammatic Representation of the Three Steps in the Taste-cell Transduction. Step 1, interaction of stimulus (S) with membrane-bound receptor (R) to form stimulus-receptor complex (SR) step 2, conformational change (SR) to (SR), brought about by interaction of S with R (this change initiates a change in plasma-membrane conformation of taste cells, probably below the level of the tight junction) and step 3, conformational changes of the membrane result in lowered membrane resistance, and the consequential influx on intracellular ionic species, probably Na. This influx generates the receptor potential which induces synaptic vesicular release to the innervating, sensory nerve, leading to the generator potential.

The Transient Receptor Potential Vanilloid 1 (TRPVl) (vanilloid receptor 1)... 

The intracellular processes which precede membrane activation appear to differ from those of MOE neurones, in that cyclic nucleotide gating may not occur. The transduction process which induces current flow in snake VN neurones, utilises as a putative second-messenger the modulator compound inositol triphosphate — Ins. (1,4,5) P3 = IP3 (Liu et al, 1999 Taniguichi et al, 2000). The proposed channel component associated with the microvillous membrane is one of the transient receptor potential family (TRPC-2 Heading Fig., pp. 94), the p-splice... 

Hofmann T., Schaefer M., Schultz G. and Gudermann T. (2000a). Transient receptor potential channels as molecular substrates of receptor-mediated cation entry. J Mol Med 78, 14-25. 

Matsumoto, R.R., Liu, Y., Lemer, M., Howard, E.W., Brackett, DJ. Sigma receptors potential medications development target for anti-cocaine agents. Eur. J. Pharmacol. 469 1, 2003. 

Zmijewski, M., Gillespie, T.A., Jackson, D.A. etal. (2006) Application of biocatalysis to drug metabolism preparation of mammalian metabolites of a biaryl-bis-sulfonamide AMPA (a-amino-3-hydroxy-5-methylisoxazole-4-propionic acid) receptor potentiator using Actinoplanes missouriensis. Drug Metabolism and Disposition The Biological Fate of Chemicals, 34, 925—931. 

Perez, C. A. et al. A transient receptor potential channel expressed in taste receptor cells. Nat. Neurosci. 5 1169-1176, 2002. 

Is this system relevant for hair cells It does not appear so. Indeed, there appear to be at least two broad classes of mechanoreceptors, one like those of C. elegans touch neurons that rely on DEG/ENaC channels, and another class that apparently relies on transient receptor potential (TRP) channels. As we will see later, circumstantial evidence suggests that hair cells use TRP channels. Other mechanoreceptors in vertebrates may be related to C. elegans touch cells. 

The molecules that transduce noxious heat or cold are members of the transient receptor potential (TRP) receptor family 929 Receptors that transduce mechanical stimuli are members of the Degenerin family 930... 

The molecules that transduce noxious heat or cold are members of the transient receptor potential (TRP) receptor family. TRP proteins (Table 57-2) form tetra-meric nonselective cation channels within the plasma membrane, allowing sodium and calcium ion influx [4]. The TRPV3 channel is activated at temperatures between 31 and39°C, TRPV1 at43°C, and TRPV2 at 52-55°C. The heat pain threshold in humans is 43°C, suggesting that... 

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