Drugs Future Potential

Aapro MS 5-HT3 receptor antagonists an overview of their present status and future potential in cancer therapy-induced emesis. Drugs 42 551-568, 1991... 

E. Palomino, E. H. Walker, S. L. Blumenthal, Carbohydrate Prodrugs Potential Use for in situ Activation and Drug Delivery , Drugs Future 1991, 16, 1029 - 1037. 

Ohtsuo T, Aoki Y. N-myristoyltransferase inhibitors as potential antifungal drugs. Drugs Future 2003 28 143-52. 

Current status and future potential. CNS Drugs 13 421-431 Huerta PT, Sun LD, Wilson MA, Tonegawa S (2000) Formation of temporal memory requires NMDA receptors within CAl pyramidal neiuons. Neuron 25 473-480 Huntsman MM, Tran BV, Potkin SG, Bimney Wejr, Jones EG (1998) Altered ratios of alternatively spliced y2 subunit of mRNAs of GABAa receptors in prefrontal cortex of schizophrenics. Proc Natl Acad Sci U S A 95 15066-15071 Huntsmann MM, Porcello DM, Homanics GE, DeLorey TM, Huguenard JR (1999) Reciprocal inhibitory connections and network synchrony in the mammalian thalamus. Science 283 541-543... 

Khor TO, Ibrahim S, Kong AN. Toxicogenomics in drug discovery and drug development potential applications and future ehallenges. Pliarm Res 2006 23 1659-1664. 

Prausnitz MR, Mitragotri S, Langer R. Current status and future potential of transdermal drug delivery. Nature Rev Drug Discov 2004 3 115-124. 

Future Potential for Dissolution Controlled Release Drug Delivery Systems... 

The choice of a cell line to study MDR modulator potency was very important for future potential application in human cancer treatment. PhM (12) that were quite effective in resistant mouse lymphoma cells were only slightly active in drug-resistant human sarcoma cell line MES-SA/Dx5 [198]. The drug-sensitive human sarcoma cell line MES-SA and its multidrug-resistant counterpart MES-SA/Dx5 were applied as a model system for evaluation of MDR modulator activities. Examination performed by the flow cytometric Rhl23 accumulation test demonstrated that the well-known P-gp modulators verapamil (79) and TFP (5) reduced MDR in MES-SA/Dx5 cells. In resistant MES-SA/Dx5 cells, verapamil (79) and TFP (5) restored the drug accumulation pattern which was typical for sensitive cells. However, the effectiveness of PhM (12) was very low. The most active compounds were derivatives with an H atom at position 2 of the phenothiazine ring, followed by Cl-substituted and CF3-substituted compounds. 

One of these methods is NAMFIS (NMR Analysis of Molecular Flexibility in Solution) [62], which considers all candidate conformations that are theoretically accessible to the molecule and optimizes their mole fractions until their computed variables match the experimental NMR data (usually NOEs and J couplings, in the future potentially also residual dipolar couplings). NAMFIS has been used to analyze the solution structures of several tubulin-binding drugs, such as PTX [63], epothilones [26], discodermolide [60] or laulimalide [64],... 

The purpose of this overview chapter is to provide perspectives in the current status and future prospects of controlled release drug delivery. This is accomplished by examining various delivery systems from a mechanistic point of view, exploring applications of these systems, and discussing relevant biopharmaceutical parameters. A major section of this book is devoted to fundamental issues and applications of transdermal and transmucosal delivery systems (Chapter 6,8,17-23). Other developing systems of future potential... 

Jensen PR, Fenical W. Marine microorganisms and drug discovery current status and future potential. In Drugs from the Sea. Fusetani N, ed. 2000. Karger, Basel pp. 6-29. 

Kennedy, F.P. Recent developments in insulin delivery techniques current status and future potential. Drugs 1991, 42, 213. 

Kontoghiorghes GJ. Clinical use, therapeutic aspects and future potential of deferiprone in thalassemia and other conditions of iron and other metal toxicity. Drugs Today (Bare) 2001 37(l) 23-35. 

Piccart MJ, Lamb H, Vermorken JB. Current and future potential roles of the platinum drugs in the treatment of ovarian cancer. Ann Oncol 2001 12(9) 1195-203. 

Weitz JI, Crowther MA. New anticoagulants Current status and future potential. Am J Cardiovasc Drugs 2003 3 201-209. 

Orfanos, C.E., Zouboulis, C.C., Almond-Roesler, B. and Geilen, C.C. (1997) Current use and future potential role of retinoids in dermatology. Drugs, 53, 358-388. 

---