Antifungal potential

An effective treatment is griseofulvin (49). It is administered orally at 10 mg kg-1. The isothiazole etisazole (50) can also be used to treat dermal fungal infections. Other heterocyclic drugs with antifungal potential have been reviewed (78MI10800). 

Brugmans, J., et al. 1972. Systemic antifungal potential, safety, biotransport and transformation of miconazole nitrate. Eur J Clin Pccrmacol 5 93. 

Pandey, R., Ahmad, Z., Sharma, S., and Khuller, G. K. (2005), Nano-encapsulation of azole antifungals Potential applications to improve oral drug delivery, Int. J. Pharm., 301(1-2), 268-276. 

Saturated and unsaturated free fatty acids may have antifungal potential, which effectiveness increases with their chain length (Kamem et al., 2009). An important role on microbial cells activity is played by hydrophobic groups of saturated fatty acids. The hydrophobicity increases with increasing the chain length, thus the solubility of fatty acids in aqueous environments decreases which prevents some interactions between these hydrophobic groups and the acyl chains of the membranes phospholipids. 

For example, Ghorab and coworkers exploited the classical Biginelli reaction to synthesize a variety of potentially active antifungal agents such as 56 from DHPM 55. ... 

PCP is commonly used as a wood preservative having both antifungal and insecticide properties. It has also been used in a range of areas for antifungal, antibacterial, general herbicide, and slime prevention in both industrial and consumer applications. Chronic exposure to PCP has effects on the liver, kidneys, and immune system. PCP also has the potential to cause reproductive problems and has been listed as a probable carcinogen. 

Potential adverse effects that may occur with antifungal therapy... 

Along with selecting an effective treatment, selection of an appropriate antifungal agent requires consideration of location and severity of infection, medication adherence, potential drug... 

The approach to antifungal therapy in patients with endemic fungal infections is determined by the severity of clinical presentation, the patient s underlying immunosuppression, and potential toxicities and drug interactions associated with antifungal treatment. 

All azole antifungals carry the potential for rash, photosensitivity, and hepatotoxicity. In general, hepatotoxicity is mild and reversible, presenting as asymptomatic increases in liver transaminases. However, fulminant hepatic failure has been reported with itraconazole. Therefore, serial monitoring of liver function... 

Ferretti, R., Gallinella, B., La, T.F., Zanitti, L. (1988). Direct resolution of a new antifungal agent, voriconazole(UK-109,496) and its potential impurities, by use of coupled achiral-chiral high-performance liquid chromatography. Chromatographia 47, 649-654. 

Temeyer tested the toxicity of miconazole and six other antifungal agents and solvents for use in horn fly larval rearing or bioassays. Each of which appeared to be potentially useful in bovine fecal medium [99],... 

Therefore, mRNA capping represents a potentially useful target for inhibitors with antifungal or antiviral activity indeed, whole-yeast cell-based assays developed to identify and characterize inhibitors of fungal mRNA capping allowed the identification and characterization of... 

Sathe SJ, Nawani NN, Dhakephalkar and Kapadnis BP. 2007. Antifungal lactic acid bacteria with potential to prolong shelf-life of fresh vegetables. J Appl Microbiol 103 2622-2628. 

The facile conversion of carbonyl groups into lactones via cyclobutanones offers many opportunities for synthetic applications considering the importance of butanol-ides in natural products synthesis. The iridoids vividly illustrate this potential. Allamandin (163) 135 c) and its dehydrated relative plumericin (164) 135 d), compounds possessing antifungal, antibacterial, and antitumor activity, pack a great deal of... 

The Wittig reaction was employed to fuse diene 49 and aldehyde 50, in the final stages of the stereoselective synthesis of epothilone B, a macrocyclic compound with potential antifungal properties (equation 31)49. 

Chapter 4 - Propolis has been used for as a traditional medicine in Eastern Europe as an antifungal, antimicrobial, antiviral, anti-inflammatory, and anticarcinogenic agent. The author isolated three cinamic acid derivatives and one flavanol derivative from Brazilian propolis and determined their structures by spectroscopic analysis. Results were assayed, the anticancer drug potential of these compounds to identify new drug candidates, by determining the... 

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