Activity modulation

Malim MH, Hauber J, Fenrick R, Cullen BR (1988) Immunodeficiency virus rev trans-activator modulates the expression of the viral regulatory genes. Nature 335 181-183... 

Jones, B. E. (2004). Activity, modulation and role of basal forebrain cholinergic neurons innervating the cerebral cortex. Prog. Brain Res. 145, 157-69. 

Postsynaptic mGluR activation modulates ion channel activity 283... 

Pijnappel WW, Hendriks HE, Folkers GE, Brink van den CE, Dekker EJ, et al. 1993. The retinoid ligand 4-oxo-retinoic acid is a highly active modulator of positional specification. Nature 366 340-344. 

Kajkowski, E.M., Lo, C.F., Ning, X., et al. (2001) Beta-amyloid peptide-induced apoptosis regulated by a novel protein containing a G protein activation module. J. Biol. Chem., 276, 18748-18756. 

In this chapter, we will focus on a class of natural products, epigenetic compounds which activate, modulate or inhibit HDACs. 

Additional assays have surfaced on both ends of the scale of complexity. Single end point assays such as those for a host of receptor binding and activation assays and enzyme activity modulation assays have been developed and applied to alternative developmental toxicity testing. These assays can be carried out in a... 

Wilden, P.A. Kahn, C.R. The level of insulin receptor tyrosine kinase activity modulates the activities of phosphatidylinositol 3-kinase, microtubule-associated protein, and S6 kinases. Mol. Endocrinol., 8, 558-567 (1994)... 

Some NSAIDs show anti-inflammatory and antiproliferative effects independent of their COX activity. Modulation of intracellular signalling pathways might contribute to these activities (Tegeder et al., 2001). A key question with respect to those additional activities is whether or not concentrations of the respective compound at the presumed sites of actions is sufficient in order to add to the main mode of action, COX inhibition. 

Philipp S, Yang XM, Cui L, Davis AM, Downey JM, Cohen MV (2006) Postconditioning protects rabbit hearts through a protein kinase C-adenosine A2b receptor cascade. Cardiovasc Res 70(2) 308-314 Platts SH, Duling BR (2004) Adenosine A3 receptor activation modulates the capillary endothelial glycocalyx. Circ Res 94(l) 77-82... 

Sanbongi C, Suzuki N, Sakane T. 1997. Polyphenols in chocolate, which have antioxidant activity, modulate immune functions in humans in-vitro. Cell Immunol 177 129-136. 

Martins R. A., Silveira M. S., Curado M. R., Police A. I., and Linden R. (2005). NMDA receptor activation modulates programmed cell death during early post-natal retinal development a BDNF-dependent mechanism. J. Neurochem. 95 244-253. 

PH Weinreb, LE Quadri, CT Walsh, P Zuber. Stoichiometry and specificity of in vitro phosphopantetheinylation and aminoacylation of the valine-activating module of surfactin synthetase. Biochemistry 37 1575-1584, 1998. 

---