P-tubulin binding

Thus, the fluorine probe approach has proved useful for the conformational analysis of paclitaxel and taxoids in connection with the determination of possible bioactive conformations.77 The previously unrecognized conformer C might be the molecular structure first recognized by the P-tubulin binding site on microtubules. 

Chart 11 Potential interaction pattern of PTX in the P-tubulin binding site. Dashed lines represent potential hydrogen bonds between the ligand and the protein residues [46]... 

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