Genetic polymorphisms in drug-metabolizing enzymes

It has now been established that genetic polymorphisms in drug metabolizing enzymes such as the cytochrome P450s (CYP) and the phase II enzyme, thiopu-rine methyltransferase, are responsible for inter-individual variability in response and adverse reactions [12, 13]. However, at the present time, the impact of poly-... 

TABLE 6—1. Selected Examples of Genetic Polymorphisms in Drug-Metabolizing Enzymes and Response to Drug Therapy... 

Nebert DW. Polymorphisms in drug-metabolizing enzymes what is their clinical relevance and why do they exist Am J Hum Genet 1997 60 265-271. 

Tanaka E. Update genetic polymorphism of drug metabolizing enzymes in humans. J Clin Pharm Ther 1999 24 323-329. 

Nebert, D.W., "Polymorphisms in Drug-Metabolizing Enzymes What is Their Clinical Relevance and Why Do They Exist ," Am. J. Hum. Genet., 60, 265-271 (1997). 

Yang M, Kunugita N, Kitagawa K, Kang SH, Coles B, Kadlubar FF, Katoh T, Matsuno K, Kawamoto T (2001) Individual differences in urinary cotinine levels in Japanese smokers relation to genetic polymorphism of drug-metabolizing enzymes. Cancer Epidemiol Biomarkers Prev 10 589-593... 

Genotypic variants occur with regard to the metabolism of isoniazid. What other drugs exhibit such variation, and what enzymes are involved in their metabolism What are the clinical consequences of genetic polymorphisms in drug metabolism The Skill Keeper Answer appears at the end of the chapter. 

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