Polymorphic drug metabolizing enzymes

Rae, J. M., Cordero, K. E., Scheys, J. O., Lippman, M. E., Flockhart, D. A., and Johnson, M. D. (2003) Genotyping for polymorphic drug metabolizing enzymes from paraffin-embedded and immunohistochemically stained tumor samples. Pharmacogenetics. 13, 501-507. 

Table 1 Some Examples of Firmly Established Polymorphic Drug Metabolizing Enzymes and Substrate Drugs ...

Table 12.3 Selected Substrates of Polymorphic Drug Metabolizing Enzymes...

Polymorphic metabolism Genetically determined rates of metabolism (fast vs. slow) by selected isozymes of cytochrome P-450 drug-metabolizing enzymes. 

Nebert DW. Polymorphisms in drug-metabolizing enzymes what is their clinical relevance and why do they exist Am J Hum Genet 1997 60 265-271. 

It has now been established that genetic polymorphisms in drug metabolizing enzymes such as the cytochrome P450s (CYP) and the phase II enzyme, thiopu-rine methyltransferase, are responsible for inter-individual variability in response and adverse reactions [12, 13]. However, at the present time, the impact of poly-... 

Tanaka E. Update genetic polymorphism of drug metabolizing enzymes in humans. J Clin Pharm Ther 1999 24 323-329. 

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