Drug-Metabolizing Enzyme s

Siess, M. H., Le Bon, A. M., Canivenc-Lavier, M. C., Amiot, M. ]., Sabatier, S., Yaubert, S. Y., and Suschetet, M. (1996). Flavonoids of honey and propolis Characterization and effects on hepatic drug-metabolizing enzymes and benzoja] pyrene-DNA.. Agric. Food Chem. 44, 2297-2301. 

Campbell, M.A., S. Bandiera, L. Robertson, A. Parkinson, and S. Safe. 1983. Hepta-, hexa-, tetra- and dichloronaphthalene congeners as inducers of hepatic microsomal drug-metabolizing enzymes. Toxicology 26 193-205. 

Streetman, D.S., et al., "Phenotyping of Drug-Metabolizing Enzymes in Adults A Review of In-Vivo Cytochrome P450 Phenotyping Probes," Pharmacogenetics, 10, 187-216 (2000). 

Miley, M.J., Zielinska, A.K., Keenan, J.E., Bratton, S.M., Pandya, A.R. andRedinbol, M.R. (2007) Crystal structure of the cofactor-binding domain of the human phase II drug-metabolism enzyme UDP-glucuronosyltransferase 2B7. Journal of Molecular Biology,... 

Sheweita, S.A. (2000) Drug-metabolizing enzymes mechanisms and functions. Current Drug Metabolism, 1, 107-132. 

Mills, J.B., Rose, K.A., Sadagopan, N., Sahi, J. and de Morais, S.M. (2004) Induction of drug metabolism enzymes and MDR1 using a novel human hepatocyte cell line. The Journal of Pharmacology and Experimented Therapeutics, 309, 303-309. 

Lu, A.Y.H., Somogyi, A., West, S., Kuntzman, R., and Conney, A.H. Pregnenolone- 16a-carbonitrile A new type of inducer of drug-metabolizing enzymes. Arch. Biochem. Biophys. 

Mankowski, D.C. and Ekins, S. (2003) Prediction of human drug metabolizing enzyme induction. Curr. Drug Metab.,... 

Robertson LW, Parkinson A, Bandicra S, et al. 1981. Potent induction of rat liver microsomal, drug-metabolizing enzymes by 2,3,3, 4,4, 5-hexabromobiphenyl, a component of Firemaster. Chem Biol Interact 35 13-24. 

It has only been discovered relatively recently that a natural remedy, St. John s Wort, used by millions for the treatment of depression, is a potent inducer of the major human drug-metabolizing enzyme, CYP3A4. This induction can lead to the therapeutic failure of a drug when the remedy is taken at the same time. 

VandenBranden M, Wrighton SA, Ekins S, Gillespie JS, Binkley SN, Ring BJ, Gadber-ry MG, Mullins DC, Strom SC, Jensen CB (1998) Alterations in the catalytic activities of drug-metabolizing enzymes in cultures of human liver slices. Drug Metab Dispos 26, 1063-1068. 

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