Drug-metabolizing enzyme activities

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Table I. Drug-metabolizing enzyme activities in liver of animals.

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Khan SG, Ali S, Rahman Q. 1992. Interaction of mineral fibres with lung cytochrome P-450 system Impairment of drug metabolizing enzyme activities. Chemosphere 24 959-968. 

The ability of the drug in question to induce drug-metabolizing enzyme activities is evaluated. If the drug in question is an inducer of a specific pathway, it... 

The test article is not metabolized by liver microsomes, or hepato-cytes This is indicated by the lack of either metabolite formation or parent disappearance in Studies 1 and 2. Hepatic metabolism is not involved in the metabolic clearance of the compound. There should be no concern with coadministered drugs that can alter drug-metabolizing enzyme activities. 

Short, C.R. Davis, L.E. (1970) Perinatal development of drug-metabolizing enzyme activity in swine. Journal of Pharmacology and Experimental Therapeutics, 174,185-196. 

Soyka LF. 1980. Hepatic drug metabolizing enzyme activity and tumorigenesis in mice following perinatal exposure to benzo(a)pyrene. Pediatr Pharmacol 1 85-96. 

Quantitative Characterization of Drug Metabolizing Enzyme Activities This section is intended to oudine the broad strategy for assessing drug metabolizing enzyme activities. For specific technical details, refer to classic techniques that have been described by... 

The activity of CYP3A isoenzymes in the human fetal liver is similar to that seen in adult liver microsomes. The fetal activity for CYP3A7 isoenzyme is unusual as most other fetal isoenzymes of CYP450 exhibit 5 to 40% of fhe adulf isoenzymes. Fetal and neonatal drug-metabolizing enzyme activities may differ from those in the adult. 

Hewitt NJ, Lloyd S, Haydan M, Butler R, Sakai Y, Springer R, Fackett A, and Li AP (2002) Correlation between troglitazone cytotoxicity and drug metabolic enzyme activities in cryopreserved human hepatocytes. Chem Biol Interact 142 73-82 Holcik M, Sonenberg N (2005) Translational control in stress and apoptosis. Nature Rev Mol Cell Biol 6 318-327... 

Sotaniemi, E. A., Pelkonen, R. 0. and Puukka, M. Measurement of hepatic drug-metabolizing enzyme activity in man. Eur. J. Clin Pharmacol. 17 267-274. 

Freeman DJ, Laupacis A, Keown P, StiUer C, Carruthers G. The effect of agents tiiat alter drug metabolizing enzyme activity on the pharmacokinetics of cyclosporme. AnnR CollPl -sicians Surg Can ( 9S4) 17, 301. 

Obach RS (2012) Heterotropic effects on drug-metabolizing enzyme activities in vitro curiosity emerges as a clinically meaningful phenomenon (perhaps ). Clin Pharmacol Ther 91 385-387... 

Table 10 Biologic half-life of hexobarbital and relative drug metabolizing enzyme activity in various species...

Allowing for the sex difference in rats, the correlation of the relative drug-metabolizing enzyme activity and body size is excellent. The correlation be-... 

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