Genetic polymorphisms drug-metabolizing enzymes

Polymorphic metabolism Genetically determined rates of metabolism (fast vs. slow) by selected isozymes of cytochrome P-450 drug-metabolizing enzymes. 

Nebert DW. Polymorphisms in drug-metabolizing enzymes what is their clinical relevance and why do they exist Am J Hum Genet 1997 60 265-271. 

It has now been established that genetic polymorphisms in drug metabolizing enzymes such as the cytochrome P450s (CYP) and the phase II enzyme, thiopu-rine methyltransferase, are responsible for inter-individual variability in response and adverse reactions [12, 13]. However, at the present time, the impact of poly-... 

Tanaka E. Update genetic polymorphism of drug metabolizing enzymes in humans. J Clin Pharm Ther 1999 24 323-329. 

Nebert, D.W., "Polymorphisms in Drug-Metabolizing Enzymes What is Their Clinical Relevance and Why Do They Exist ," Am. J. Hum. Genet., 60, 265-271 (1997). 

Yang M, Kunugita N, Kitagawa K, Kang SH, Coles B, Kadlubar FF, Katoh T, Matsuno K, Kawamoto T (2001) Individual differences in urinary cotinine levels in Japanese smokers relation to genetic polymorphism of drug-metabolizing enzymes. Cancer Epidemiol Biomarkers Prev 10 589-593... 

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