Cytochrome P450 enzymes drug metabolism

Abelo, A., Andersson, T.B., Antonsson, M., Naudot, A.K., Skanberg, I. and Weidolf, L. (2000) Stereoselective metabolism of omeprazole by human cytochrome P450 enzymes. Drug Metabolism and Disposition, 28 (8), 966-972. 

Obach, S.R. and Dalvie, D.K. (2006) Metabolism of nomifensine to a dihydroisoquinolinium ion metabolite by human myleoperoxidase, hemoglobin, monamine oxidase A, and cytochrome P450 enzymes. Drug Metabolism and Disposition, 34, 1310-1316. 

Cytochrome P450 System - Drug-metabolizing Enzymes... 

As soon as the drug enters the body, in addition to being distributed to other parts of the body, it begins to break down. Most small-molecule drug metabolism occurs in the liver by enzymes termed cytochrome P450 enzymes. As metabolism occurs, the parent compound is converted to metabolites, which could be pharmacologically inert or active. 

To correctly predict overall oral absorption, drug metabolism in intestinal epithelial cells by cytochrome P450 enzymes should also be considered. The prediction of drug metabolism has already been covered in detail in Chapter 18. 

Trubetskoy, O.V., Gibson, J.R., and Marks, B.D. 2005. Highly miniaturized formats for in vitro drug metabolism assays using vivid fluorescent substrates and recombinant human cytochrome P450 enzymes. J. Biomol. Screen. 10 56. 

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