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Nasal epithelium drug-metabolizing enzymes

The nasal route of drug delivery avoids the liver first-pass effect, but the pseudo-first-pass effect owing to nasal metabolism of drugs is still a concern. Many enzymes such as carboxylesterase, aldehyde dehydrogenase, glutathione transferases, UDP-glucoronyl transferase, epoxide hydrolases, CYP-dependent monoxygenases, exo- and endopeptidases and proteases are present in the nasal mucosa.106 108,110,116 CYP enzymes are present abundantly in the olfactory epithelium.107,110... [Pg.63]

See other pages where Nasal epithelium drug-metabolizing enzymes is mentioned: [Pg.117]    [Pg.119]    [Pg.362]    [Pg.376]    [Pg.90]    [Pg.597]    [Pg.228]    [Pg.596]    [Pg.43]    [Pg.478]    [Pg.480]   
See also in sourсe #XX -- [ Pg.125 ]



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Drug metabolism enzymes

Drug metabolism nasal

Drug-metabolizing enzymes

Enzymes drugs

Epithelia, epithelium

Metabolic enzymes

Metabolism enzymes

Metabolizing enzymes

Nasal

Nasal metabolism

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