Streptomycin Doxycycline

The recommended treatment is doxycycline (200 mg/day) plus rifampin (600 mg/day) for six weeks. An alternative effective treatment is six weeks of doxycycline (200 mg/day) plus streptomycin (1 gm/day) for three weeks. Trimethoprim-sulfamethoxazole given four to six weeks is less effective. In 5 to f 0 percent of cases, there may be a relapse or treatment failure. Regarding prophylaxis, killed and live attenuated human vaccines are available in many countries but are considered of unproven efficacy. There tends to be no information on the use of antibiotics for prophylaxis against human brucellosis. 

Drugs Use streptomycin at 15 mg/kg lean body mass intra-muscular every twenty-four hours for ten to fourteen days or use gentamicin at 5 mg/kg lean body mass intra-venous every twenty-four hours for ten to fourteen days or use gentamicin at 1.75 mg/kg lean body mass intra-venous every eight hours for ten to fourteen days or use ciprofloxacin at 400 mg intra-venous every twelve hours (oral therapy may be given at 750 mg orally every twelve hours after the patient is clinically improved, for completion of a ten to fourteen-day course of therapy) or use doxycycline at 200 mg intra-venous loading dose followed by 100 mg intra-venous every twelve hours (oral therapy may be given at 100 mg orally every twelve hours after the patient is clinically improved, for completion of a ten to fourteen-day course of therapy. 

Treatment — No vaccines are available for humans. Glanders may be treated with sulfadiazine, doxycycline, rifampin, trimethoprim-sulfamethoxazole, streptomycin, and ciprofloxacin.3... 

Sulfadiazine, doxycycline, rifampin, trimethoprim-sulfamethoxazole, streptomycin, ciprofloxacin... 

The historical antibiotic of choice for the treatment of plague has been streptomycin. Gentamicin is another preferred antibiotic. Alternative regimens include doxycycline, ciprofloxacin, and chloramphenicol. Patients with pneumonic plague may also require advanced medical supportive therapy in addition to antibiotics. 

As for the treatment of plague, streptomycin and gentamicin are the drugs of choice. Doxycycline and chloramphenicol have also been used, but more treatment failures have been reported with these regimens. Ciprofloxacin is another alternative therapy. For the first-line regimens as well as ciprofloxacin, a 10-day course of intravenous antibiotics is recommended. For second-line therapies, 14 days are recommended. 

Plague Greer inactivated Streptomycin 30 mg/ Doxycycline 100 mg PO bid Plague vaccine not... 

Children Preferred choices Streptomycin, 15 mg kg IM twice daily (maximum daily dose, 2g) Gentamicin, 2.5 mg kg IM or IV three times daily Alternative choices Doxycycline If >45kg, give adult dosage If <45kg, give 2.2mg kg twice daily (maximum, 200mg d- ) Ciprofloxacin, 15 mg kg IV twice daily Chloramphenicol, 25 mg kg IV four times daily" ... 

Treatment with streptomycin, gentamicin, or ciprofloxacin should be continued for 10 days, treatment with doxycycline or chloramphenicol should be continued for 14-21 days. Persons beginning treatment with IM or IV doxycycline, ciprofloxacin, or chloramphenicol can switch to oral antibiotic administration when clinically indicated Not a US FDA - approved use... 

Treatment begun with streptomycin, gentamicin, doxycycline, or ciprofloxacin during the incubation period and continuing for 14 days may prevent symptomatic infection (43). A small study in volunteers showed that oral tetracycline given within 24h of an aerosol exposure and continued for 14 or 28 days was fully protective, whereas two out of ten volunteers treated for only 5 days developed symptomatic tularemia after stopping treatment. Once pubUc health officials become aware that... 

Antibiotic therapy is highly effective in treating tularemia and significantly reduces fatalities, including drugs such as streptomycin, gentamicin, doxycycline. 

Brucella are facultative intracellular gram-negative bacilli. Humans are infected by this organism after ingesting infected unpasteurized milk or undercooked meat, inhalation of infectious aerosols, or contact with infected tissues. This type of IE is more common in veterinarians and livestock handlers. Cure requires valve replacement and antimicrobial agents including doxycycline with streptomycin or gentamicin or doxycycline with trimethoprim-sulfamethoxazole or rifampin for an extended period (8 weeks to months)." ... 

Multiple-antibiotic-resistant enterococci—Many Enterococcus spp. are now resistant to penicillin and ampi-cillin, gentamicin or streptomycin or both, and to vancomycin. Some of these strains are snsceptible in vitro to chloramphenicol, doxycycline or flnoroqninolones, bnt clinical results with these drugs have been variable. 

Ceftazidime chloramphenicol imipenem Streptomycin -i- chloramphenicol imipenem Meropenem chloramphenicol -i- doxycycline + trimethoprim-sulfameflioxazole amoxicillin/clavulanic acid Doxycycline or ciprofloxacin gentamicin... 

Nocardia infections have been treated successjully, but failures also have been reported. Although a combination of doxycycline and streptomycin or gentamicin is considered the treatment of choice for brucellosis, trimethoprim—sulfamethoxazole may be an effective substitute for the doxy-cyctine combination. Trimethoprim—sulfamethoxazole also has been used successjully for Whipple s disease, Stenotrophomonas maltophilia infection, and infection by the intestinal parasites Cyclospora and Isospora. 

Brucellae are sensitive in vitro to a number of oral antibiotics and to aminoglycosides. Therapy with a single drug has resulted in a high relapse rate, so combined regimens should be used whenever possible.47 A 6-week regimen of doxycycline 200 mg/d administered orally, with the addition of streptomycin 1 g/d administered intramuscularly for the first 2 to 3 weeks is effective therapy for adults with most forms of brucellosis.48 Patients with spondyli-... 

Endocarditis may best be treated with rifampin, streptomycin, and doxycycline for 6 weeks infected valves should be replaced early in therapy.52 Central nervous system disease responds to a combination of rifampin and trimethoprim/sulfamethoxazole, but may need prolonged therapy. The latter antibiotic combination is also effective for children under 8 years of age.53 The Joint Food and Agriculture Organization-World Health Organization Expert Committee recommends treatment of pregnant women with rifampin.49... 

Nearly all patients respond to a 6-week course of oral therapy with a combination of rifampin and doxycycline fewer than 10% of patients relapse. Six weeks of doxycycline with addition of streptomycin for the first 3 weeks is also effective therapy. No vaccine is available for humans. 

Ariza J, Gudiol F, Pallares R, et al. Treatment of human brucellosis with doxycycline plus rifampin or doxycycline plus streptomycin A randomized, double-blind study. Ann Intern Med. 1992 117(1) 25-30. 

Yes. After potential exposure or diagnosis, early treatment is recommended with an antibiotic from the tetracycline (such as doxycycline) or fluoroquinolone (such as ciprofloxacin) class, which are taken orally, or the antibiotics. streptomycin or gentamicin, which are given... 

A meta-analysis of 6 studies involving 544 patients with brueellosis found a significantly higher numbers of relapses and lower numbers of initial cures if doxycycline was given with rifampicin rather than streptomycin. ... 

The interaction between doxycycline and rifampicin is established and of clinical importance. Monitor the effects of concurrent use and increase the doxycycline dosage as necessary. No clinically important adverse interaction appears to occur between doxycycline and streptomycin. 

Seven paralytic shellfish toxins (PSTs), namely decarbamoylsaxitoxin (dcSTX), saxitoxin (STX), neosaxitoxin (NEO), gonyautoxin-2 (GTX-2), gonyautoxin-3 (GIX-3), gonyautoxin-1 (GTX-1), and gonyautoxin-4 (GTX-4) Antibiotics residues (amoxicillin, doxycycline hydrochloride, streptomycin sulfate, thiamphenicol, florphenicol, nifursol, enrofloxacin, ciprofloxacin, norfloxacin) from poultry and porcine tissues Quinolones [enrofloxacin (ENR), ciprofloxacin (CPR), danofloxacin (DAN), difloxacin (DIF), marbofloxacin (MAR), flumequine (FLU), and oxolinic acid (OXA)] in pig kidney tissue... 

Antibiotic treatment should be continued for at least 4 weeks (i. e., until at least three doses of vaccine have been received). Penicillin and especially streptomycin are rarely used anymore, and hospital pharmacies will have very limited supplies on hand, but Pfizer will still ship streptomycin overnight. Ciprofloxacin and doxycycline are prescribed far more often, but they are expensive, especially ciprofloxacin, which may limit supplies in any one locale. 

According to Franz et al. (1997), patients should be treated with combinations of antibiotics because treatment with a single antibiotic causes poor response or relapse. Usually, a combination of doxycycline and rifampin is given orally for six weeks. Trimethoprim-sulfamethoxazole can be substituted for rifampin, although relapse rates may be as high as 30 percent (Franz et al., 1997). The recommended treatment for bone and joint infections, endocarditis, and central nervous system disease is streptomycin or another aminoglycoside, and therapy should be extended. 

Plague pneumonia is almost always fatal if treatment is not initiated within 24 hours of the onset of symptoms. Streptomycin is administered intramuscularly for 10 days (2 doses each day). Gentamicin can be substituted for streptomycin. Plague meningitis and cases of circulatory compromise are treated with chloramphenicol given intravenously. Intravenous doxycycline administered for 10 to 14 days is also effective. 

Plague is sensitive to streptomycin, tetracycline, chloramphenicol, and gentamicin, but weaponized plague bacteria may be genetically engineered to be resistant to these antibiotics. Aggressive antibiotic treatment must be started within 18 to 24 hours of onset of symptoms if the patient is to be saved. If there is a pk ue epidemic, you will need to take oral doxycycline or ciprofloxin to prevent contracting the disease. 

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