Doxycycline Rifampin

Treatment — No vaccines are available for humans. Glanders may be treated with sulfadiazine, doxycycline, rifampin, trimethoprim-sulfamethoxazole, streptomycin, and ciprofloxacin.3... 

Often treated with doxycycline, rifampin, and ofloxacin See Tierno 2002 or other medical references for details on administering medications... 

Sulfadiazine, doxycycline, rifampin, trimethoprim-sulfamethoxazole, streptomycin, ciprofloxacin... 

Brucella species Doxycycline + rifampin or aminoglycoside5 Chloramphenicol + aminoglycoside5 or TMP-SMZ1... 

Doxycycline + rifampin Brucella melitensis (human beings)... 

Colmenero, J.D. Ferndndez-Gallardo, L.C. Agundez, J.A.G. Sedeno, J. Benitez, J. Valverde, E. Possible implications of doxycycline-rifampin interaction for treatment of brucellosis. Antimicrob.Agents Chemother., 1994, 38, 2798-2802 [extracted rifampin plasma serum papaverine (IS) LOQ 200 n mL]... 

Drugs Available Doxycycline, and Rifampin (Trimethoprim-sulfamethoxazole may be substituted for rifampin, but relapse may reach 30 percent). 

The recommended treatment is doxycycline (200 mg/day) plus rifampin (600 mg/day) for six weeks. An alternative effective treatment is six weeks of doxycycline (200 mg/day) plus streptomycin (1 gm/day) for three weeks. Trimethoprim-sulfamethoxazole given four to six weeks is less effective. In 5 to f 0 percent of cases, there may be a relapse or treatment failure. Regarding prophylaxis, killed and live attenuated human vaccines are available in many countries but are considered of unproven efficacy. There tends to be no information on the use of antibiotics for prophylaxis against human brucellosis. 

Tetracycline 500 mg every six hours or doxycycline 100 mg every twelve hours for five to seven days will shorten the duration of illness, and fever usually disappears within one to two days after treatment is begun. Ciprofloxacin and other quinolones are active in vitro and should be considered for victims unable to take tetracycline or doxycycline. Successful treatment of Q fever endocarditis is much more difficult. Tetracycline or doxycycline given in combination with trimethoprim-sulfamethoxazole (TMP-SMX) or rifampin for twelve months or longer has been successful in some cases. However, valve replacement is often required to achieve a cure. 

Treatment — A number of antibiotics are available including doxycycline combined with rifampin, and ofloxacin combined with rifampin. Vaccines for animal use directed against B. melitensis and B. abortus have proven very successful. An effective vaccine for human use against B. suis is currently under development.3... 

Treatment — Various antibiotics are useful in treating Coxiella infections. They include tetracycline, doxycycline, and erythromycin. In cases of endocarditis, treatments with doxycycline combined with rifampin, and trimethoprim-sulfamethoxazole combined with doxycycline or tetracycline for 12 months or longer have been successful.3... 

Drugs that may affect barbiturates include alcohol, charcoal, chloramphenicol, MAO inhibitors, rifampin, and valproic acid. Drugs that may be affected by barbiturates include acetaminophen, anticoagulants, beta blockers, carbamazepine, chloramphenicol, clonazepam, oral contraceptives, corticosteroids, digitoxin, doxorubicin, doxycycline, felodipine, fenoprofen, griseofulvin, hydantoins, methoxyflurane, metronidazole, narcotics, phenmetrazine, phenylbutazone, quinidine, theophylline, and verapamil. 

Rifampin is known to induce the hepatic microsomal enzymes that metabolize various drugs such as acetaminophen, oral anticoagulants, barbiturates, benzodiazepines, beta blockers, chloramphenicol, clofibrate, oral contraceptives, corticosteroids, cyclosporine, disopyramide, estrogens, hydantoins, mexiletine, quinidine, sulfones, sulfonylureas, theophyllines, tocainide, verapamil, digoxin, enalapril, morphine, nifedipine, ondansetron, progestins, protease inhibitors, buspirone, delavirdine, doxycycline, fluoroquinolones, losartan, macrolides, sulfonylureas, tacrolimus, thyroid hormones, TCAs, zolpidem, zidovudine, and ketoconazole. The therapeutic effects of these drugs may be decreased. 

Brucellosis B (Brucella species) Animals— typically livestock 5-60 days Yes Standa d contact if draining lesions present Flu-like symptoms (fever, muscle aches, chills, sweating) W/ Tx— about 3 weeks can be chronic Doxycycline and rifampin... 

Tricyclic antidepressants, corticosteroids, coumarin anticoagulants, digitoxin, doxycycline, furosemide, oral contraceptives, quinidine, rifampin, theophylline, vitamin D... 

Bacillus anthracis Anthrax pneumonia Ciprofloxacin or doxycycline plus a penicillin another [alternative] agent Clarithromycin clindamycin chloramphenicol imipenem rifampin vancomycin... 

Bacillus Legionella pneumophila Common Disease(s) Legionnaires disease Primary Agent(s) Erythromycin rifampin or a fluoroquinolone Alternative Agent(s) Azithromycin or clarithromycin doxycycline trimethoprim-sulfamethoxazole... 

Legionella species Azithromycin + rifampin or quinolone + rifampin Clarithromycin, erythromycin, doxycycline... 

Most cases of Legionella pneumonia show improvement within 12-48 hours of starting antibiotic therapy. The antibiotic of choice has been erythromycin, sometimes paired with a second antibiotic, rifampin. Tetracycline, alone or with rifampin, is also used to treat Legionnaires disease, but has had more mixed success in comparison to erythromycin. Other antibiotics that have been used successfully to combat Legionella include doxycycline, clarithromycin, fluorinated quinolones, and trim ethoprim/sulfamethoxazole. 

Clinically important, potentially hazardous interactions with alprazolam, amiodarone, amphotericin B, arbutamine, bendroflumethiazide, benzthiazide, bisacodyl, bumetanide, carbimazole, chlorothiazide, chlorthalidone, cholestyramine, clarithromycin, conivaptan, cyclosporine, cyclothiazide, dan-shen, demeclocycline, devil s claw, dexmedetomidine, doxycycline, erythromycin, esomeprazole, ethacrynic acid, flunisolide, furosemide, ginseng, glycopyrrolate, glycopyrronium, hawthorn (fruit, leaf, flower extract), horsetail, hydrochlorothiazide, hydroflumethiazide, indapamide, licorice, lopinavir, mepenzolate, methyclothiazide, metolazone, minocycline, mistletoe, oxprenolol, oxytetracycline, paroxetine, phenylbutazone, polythiazide, propafenone, propantheline, quinethazone, quinidine, rabeprazole, rifampin, roxithromycin, sarsaparilla, senna, Siberian ginseng, squill, St John s wort, telithromycin, teriparatide, tetracycline, thiazide diuretics, tolvaptan, trichlormethiazide, verapamil... 

Neither doxycycline nor a fluoroquinolone may reach therapeutic levels in the cerebrospinal fluid. Therefore, ciprofloxacin augmented with chloramphenicol, rifampin, or penicillin is the treatment of choice for suspected or confirmed anthrax meningitis (4). 

Loeb, M.B. et al. (2004) A randomized, controlled trial of doxycycline and rifampin for patients with Alzheimer s... 

Erythromycin rifampin or fluoroquinolone Trimethoprim-sulfamethoxazole, clarithromycin,- azithromycin, or doxycycline ... 

B. anthracis typically is susceptible to penicillin, amoxicillin, erythromycin, doxycycline, ciprofloxacin, and chloramphenicol. The bioterrorism-related strain was susceptible to the fluoroquinolones, rifampin, tetracycline, vancomycin, imipenem, meropenem, chloramphenicol, clindamycin, and the aminoglycosides. However, the strain was resistant to third-generation cephalosporins and trimethoprim-sulfamethoxazole. Ciprofloxacin or doxycycline plus one or two of the aforementioned antibiotics is the currently recommended regimen for the treatment of inhalational anthrax, but doxycycline is not recommended for the treatment of anthrax meningitis owing to poor CNS penetration and recent in vitro resistance. ... 

Coxiella burnetii (Q fever) just recently has been recovered from blood cultnres, but infection is more likely to be identified via serologic tests. It is a common cause of IE in certain areas of the world where goat, cattle, and sheep farming are widespread. The most favorable therapy for Q fever is unknown but may include doxycycline with trimethoprim-sulfamethoxazole, rifampin, or fluoroquinalones." ... 

Brucella are facultative intracellular gram-negative bacilli. Humans are infected by this organism after ingesting infected unpasteurized milk or undercooked meat, inhalation of infectious aerosols, or contact with infected tissues. This type of IE is more common in veterinarians and livestock handlers. Cure requires valve replacement and antimicrobial agents including doxycycline with streptomycin or gentamicin or doxycycline with trimethoprim-sulfamethoxazole or rifampin for an extended period (8 weeks to months)." ... 

Cefoxitin rifampin a sulfonamide doxycycline ethambutol linezolid... 

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