Long-term depression

Long-term depression (LTD) is a synaptic plasticity phenomenon that corresponds to a decrease in the synaptic strength (decrease in the post-synaptic response observed for the same stimulation of the pre-synaptic... 

Functions of nNOS include long-term regulation of synaptic transmission in the CNS (long-term potentiation, long-term depression), whereas there is no evidence for an involvement of nNOS-derived NO in acute neurotransmission. Retrograde communication across synaptic junctions is presumed to be involved in memory... 

Locus Cemleus Long-Chain Fatty Acids Long-QT Syndromes Long-Term Depression Long-Term Potentiation Loop Diuretics... 

Other forms of synaptic plasticity include long-term depression (LTD) and NMDA-receptor-independent LTP 865... 

Bear, M. and Abraham, W. C. Long-term depression in hippocampus. Annu. Rev. Neurosci. 19 437-462,1996. 

Endocannabinoids serve as retrograde messengers. They are released by postsynaptic neurons and act on presynaptic CB1 receptors on neighboring nerve terminals. Retrograde signaling by endocannabinoids is essential for many forms of synaptic plasticity that are initiated by postsynaptic depolarization and increased postsynaptic intracellular Ca2+> but expressed as a presynaptic decrease in the probability of transmitter release. Examples include some forms of long-term depression (LTD see Ch. 53) at GABA... 

LTD long-term depression NBD nucleotide-binding domain... 

The synaptic efficacy Xi Wi is weakened or depressed, leading to long-term depression of synaptic strength. 

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Herry C, Garcia R (2002) Prefrontal cortex long-term potentiation but not long-term depression is associated with maintenance of extinction of learned fear in mice. J Neurosci 22 577-583... 

Follesa P, Ticku MK (1996) NMDA receptor upregulation molecular studies in cultured mouse cortical nem-ons after chronic antagonist exposure. J Neimosci 16 2172-2178 Fourgeaud L, Mato S, Bouchet D, et al (2004) A single in vivo exposure to cocaine abolishes endocannabinoid-mediated long-term depression in the nucleus accimibens. J Neimosci 24 6939-6945... 

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