Dopamine modulation dopaminergic

Both clinical and experimental studies have provided evidence that 5-HT can also regulate dopamine turnover. Thus several investigators have shown that a positive correlation exists in depressed patients between the homovaniUic acid (HVA), a major metabolite of dopamine, and 5-HIAA concentrations in the CSF. In experimental studies, stimulation of the 5-HT cell bodies in the median raphe causes reduced firing of the substantia nigra where dopamine is the main neurotransmitter. There is thus convincing evidence that 5-HT plays an important role in modulating dopaminergic... 

Calabresi P, Benedetti M, Mercuri NB, Bernardi G (1988) Endogenous dopamine and dopaminergic agonists modulate synaptic excitation in neostriatum Intracellular studies from naive and catecholamine-depleted rats. 

A number of azetidine-based compounds have been disclosed in patent applications from Aventis Pharma for CBi-modulated treatment of diseases such as obesity, Parkinson s disease, schizophrenia, respiratory and neurological diseases [330-334]. Compound (556) was specifically claimed for use in two formulation patent applications [330, 331] for a stable semi-solid composition and oral emulsion composition, respectively. The optional coadministration of an agent that activates norepinephrinergic and se-rotoninergic neurotransmission (for example, sibutramine) or dopaminergic neurotransmission was also claimed for the treatment of obesity. The optional use of a dopamine agonist (for example, levodopa) was claimed... 

Momiyama T., Sim J. A. (1996). Modulation of inhibitory transmission by dopamine in rat basal forebrain nuclei activation of presynaptic Dl-like dopaminergic receptors. J. Neurosci. 16(23), 7505-12. 

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