Chemical development timing

The interests of SMB for performing large-scale separations of enantiopure drugs has been recognized (very short development time, extremely high probability of success, and attractive purification cost) [68]. Several pharmaceutical and fine chemical companies have already developed SMB processes. However, because of strong confidentiality constraints, public information is limited, and some of the major announcements are summarized below ... 

For many decades, TIMS was the isotope analytical technique of choice, but due to instrumental developments in ICP-MS, especially with multiple ion collectors (MC-ICP-SFMS), and the advantages of ICP-MS in comparison to TIMS (e.g., higher element sensitivities, faster isotope ratio measurements, comparable precision and accuracy, practically no restriction on the ionization potential of chemical elements, time independent mass fractionation and the possibility of additional multi-element analysis at trace and ultratrace level and fewer, less time-consuming sample preparation steps75), TIMS will be replaced in future by powerful ICP-MS to an ever greater extent. 

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