Databases Access

The functionality available in MedChem Explorer is broken down into a list of available computational experiments, including activity prediction, align/ pharmacophore, overlay molecules, conformer generation, property calculation, and database access. Within each experiment, the Web system walks the user through a series of questions that must be answered sequentially. The task is then submitted to a remote server, where it is performed. The user can view the progress of the work in their Web browser at any time. Once complete, the results of the calculation are stored on the server. The user can then run subsequent experiments starting with those results. The Web interface includes links to help pages at every step of the process. 

ISI is available in hard copy and electronically at EPA s headquarters and regional Hbraries, and through the National Technical Information Service (NTIS). The electronic form may be installed on IBM PC-compatible computers or placed on local area networks, and mn under Microsoft WINDOWS or WordPerfect s Library program. The Macintosh version is no longer available. The 1993 update will include the ISI hardcopy, PC disks, and the PC system user manual. EPA also pubHshes ACCESS EPA, which provides sources of information, databases, and pubHcations within the EPA. Chapter 5 of that pubhcation includes important environmental databases in air and soHd waste, pesticides and toxic substances, water, and cross-program (110). EPA also provides databases accessible through EPA Hbraries, which describe the private EPA and commercial databases available to Hbrary users (111). 

EPA, Databases Accessible Through EPA Eibraries, Environmental Protection Agency, Washington, D.C. (iu press) (1994). 

Irrespective of the protocol used, communication programs act as servers to the database manager. When some functions request data from a remote node, the database manager will transfer the request to the remote node database manager via the communication programs. The remote node communication programs will relay the request to the resident database manager and return the obtained data. The remote database access and the existence of communications equipment and software are transparent to plant operators. 

The use of computers in design and related fields is widespread and will continue to expand. It is increasingly important for designers to keep up to date continually with the nature and prospects of new computer hardware and software technologies. For example, plastic databases, accessible through computers, provide product designers with property data and information on materials and... 

With regard to the common European market, the European Economic Community (EEC) has undertaken numerous activities concerned with materials and material information systems. In one demonstration program for material databases eleven such databases from various countries in the EEC are being cooperatively developed with joint standards for terminology, data presentation, database access, and the user interface of search commands, aids, and menus. For the materials class of plastics, Polymat was selected to participate in this cooperative work. Interesting developments occur from which the users of central material databases in the entire EEC area can benefit. 

Provide data that can be converted to a database accessible format... 

Several types of software were developed. One programme contains the questionnaire and allows each interviewer to upload all the answers from each interview to an internal common password-protected database accessible via the internet. Another programme displays an overview of each substep of each major step in each supply chain on a webpage, and by clicking on a... 

Due to the ready accessibility of SH2 domains by molecular biology techniques, numerous experimentally determined 3D structures of SH2 domains derived by X-ray crystallography as well as heteronuclear multidimensional NMR spectroscopy are known today. The current version of the protein structure database, accessible to the scientific community by, e.g., the Internet (http //www.rcsb.org/pdb/) contains around 80 entries of SH2 domain structures and complexes thereof. Today, the SH2 domain structures of Hck [62], Src [63-66], Abl [67], Grb2 [68-71], Syp [72], PLCy [73], Fyn [74], SAP [75], Lck [76,77], the C- and N-terminal SH2 domain ofp85a [78-80], and of the tandem SH2 domains Syk [81,82], ZAP70 [83,84], and SHP-2 [85] are determined. All SH2 domains display a conserved 3D structure as can be expected from multiple sequence alignments (Fig. 4). The common structural fold consists of a central three-stranded antiparallel ft sheet that is occasionally extended by one to three additional short strands (Fig. 5). This central ft sheet forms the spine of the domain which is flanked on both sides by regular a helices [49, 50,60]. 

Data storage and access This is the database access layer along with a logical layer above it to coordinate shared access to the data. 

Clathrates, and Related Materials, 331 pp., Springer-Verlag, Berlin, Germany. Baerlocher, G. and McCusker, LB. (2009) Database of Zeolite Structures, http // www.iza-structure.org/databases/ (accessed June 2009). 

Member States in whose territory the clinical trial takes place shall enter in a European database, accessible only to the competent authorities of the Member States, the Agency and the Commission ... 

These principles are embodied in the chemoinformatics system outlined below. This system uses a backend (for database access and computations) that... 

We will highlight this system by first giving a brief overview of the architecture, followed by some practical examples that cover several common tasks in the drug discovery process. The goal is not to give a detailed account of the methods employed, but rather to illustrate how the system functions in practice. We will present as examples some of the most widely used chemoinformatics applications customized database access, similarity and substructure searching, reactant selection, and library design. 

MDL (2006) MDL drug data report database (accessed December 2006). 

Data sources Expasy and InterPro, and NCBI databases, accessed August 2002. 

Please refer to the human apoCII sequence in the NCBI database (accession number M10612.1 at http //www.ncbi.nlm.nih.gov/entrez/query.fcgifdb = Nucleotide). 

World Wide Web -Entrez and Molecular Modeling Database access http //zvzvw.ncbi.nlm.nih.gov... 

The whole database access code is surrounded by a try-finally block. There is no catch because the exceptions are rethrown by the code. However, the finally block is necessary because the ResultSet, Statement, and Connection objects must be closed properly whether an exception is thrown, or otherwise there will be database resource leaks. The database cleanup is implemented in a Util class. The initialization of the Connection object is purposely left out from the code. It can be either from a connection pool or from a Thread Local variable that is set earlier in the method call stack. Thread Local will be discussed further in Chapter 15. 

IUPAC, IFCC (2002) Properties and units in the clinical laboratory sciences. Database accessed on http //dior.imt. liu.se/cnpu/... 

This chapter is aimed at introducing the concepts of biostatistics and informatics. Statistical analysis that evaluates the reliability of biochemical data objectively is presented. Statistical programs are introduced. The applications of spreadsheet (Excel) and database (Access) software packages to analyze and organize biochemical data are described. 

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