Danazol hormonal

Luzardo OP, Machln RP, Dlaz-Chico BN, Fernandez L (2000) Photoaffinity labeling identification of a specific binding protein for the anabolic steroids stanozolol and danazol an oligomeric protein regulated by age, pituitary hormones, and ethinyl estradiol. Endocrinology 141 3377... 

The synthesis of Lp(a) can be influenced by hormones, as is reported by Albers et al. (A7), who observed a reduction of Lp(a) concentrations in nor-molipidemic postmenopausal women treated during 6 weeks with the anabolic steroid stanazolol. The same effect was reported for norethisterone (FI) and danazol (Cl2). Exogenous estrogens, as used in treatment of postmenopausal complaints and in oral contraceptives, induce a decrease of Lp(a) (D9, H27, K13, KAO, L21, S37). This effect is dose-related and dependent on Lp(a) levels before treatment (F2). Watanabe (W9) investigated the influence of progestogen (alone) and detected a decrease of Lp(a) during treatment. 

Fibrocystic breast disease Danazol is usually effective in decreasing nodularity, pain, and tenderness, but it alters hormone levels recurrence of symptoms is very common after cessation of therapy. 

Pharmacology A synthetic androgen derived from ethisterone, danazol suppresses the pituitary-ovarian axis by inhibiting the output of pituitary gonadotropins. Danazol depresses the output of both follicle-stimulating hormone (FSH) and luteinizing... 

Danazol is a weak androgen and also has a series of other hormonal and anti-hormonal properties. It inhibits pituitary gonadotropin and has been used in the treatment of endometriosis, fibrocystic disease of the breast, idiopathic thrombocytopenic purpura, and hereditary angioedema. Its hepatotoxic effects include reversible rises in serum transaminases and cholestatic hepatitis a few cases of hepatocellular tumors have been reported. 

Danazole Gonadotropin-releasing hormone (GRH) antagonist (indirect estrogen antagonist)... 

Sex hormones and hormone antagonists. Oestrogens increase the synthesis of some vitamin K dependent clotting factors and progestogen-only contraceptives are preferred. The hormone antagonists danazol, flutamide and tamoxifen enhance the effect of warfarin. 

Cyclical breast pain or mastalgia, when severe, may respond to continuous use of gamolenic acid (Efamast) (orally) it is an essential unsaturated fatty acid for cell membranes (patients have low concentrations) it may act by reducing cellular uptake of prolaction and ovarian hormones. Danazol and bromocriptine also help. 

The most common drugs responsible for acneform eruptions are ACTH, androgenic hormones, anticonvulsants (hydantoin derivatives, phenobarbital, trimethadione), corticosteroids, danazol, disulfiram, halogens (bromides, chlorides, iodides), lithium, oral contraceptives, tuberculostatics (ethionamide, isoniazid, rifampin), vitamins B2, B6, and B12. 

Ovulation suppression (e.g., oral contraceptives, danazol, gonadotropin-releasing hormone agonists) should be used before resorting to surgical therapy in women with severe PMDD. 

Nonsteroidal anti-inflammatory drugs ibuprofen, ketoprofen, naproxen sodium Alternative bromocriptine, danazol, oral contraceptives, gonadotropin releasing hormone agonist estrad iol/progesterone add-back therapy Migraines Caffeine restriction... 

Serotonin reuptake inhibitor (intermittent or continuous with increase in dose during luteal phase) Alternative danazol or gonadotropin-releasing hormone agonist for 2-3 cycles (if longer treatment, estradiol progesterone add-back therapy may be required)... 

By inducing anovulation with various hormonal therapies, the cyclicity of PMS disappears. Anovulation can be induced by estradiol implants, high doses of progesterones, OCs, GnRH-As, and danazol. For the perimenopausal syndrome, the replacement of hormones such as 17/S-estradiol, progesterone (if the uterus is intact), and testosterone is used to stabilize the deficiency and fluctuations in hormone levels. 

All medical therapies (nonsteroidal anti-inflammatory drugs, oral contraceptives, progestins, danazol, or gonadotropinreleasing hormone agonists) are equally efficacious in treating endometriosis-related pain based on available evidence. Choice among agents is determined primarily by side-effect profile, cost, and individual patient response. 

Danazol is a sex hormone that suppresses the pituitary-ovarian axis by inhibiting output of pituitary gonadotropins has weak, dose-related androgenic activity with no estrogenic or progestational activity. Danazol is indicated in treatment of endometriosis symptomatic treatment of fibrocystic breast disease and in prevention of attacks of hereditary angioedema. 

There is a theoretical risk that the effects of danazol or gestrinone and hormonal contraceptives might be altered or reduced by concurrent use. 

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