Gamolenic acid

Black cohosh 2. Caffeine 3. Evening primrose oil 4. Scutellaria baicalensis 5. Starflower (borage) 1. Docetaxel 2. Paditaxel 3. Doxorubicin 4. Tamoxifen 5. Cisplatin 6. Vinorelbine t cytotoxic properties Unknown mechanism (black cohosh). Caffeine t cytotoxic effects of cisplatin wogonin present in Scutellaria enhances etoposide-induced apoptosis. Gamolenic acid found in evening primrose oil and borage potentiated the in vitro toxicity of paditaxel and vinorelbine, attributed to an unsaturated fatty acid as modulators of tumour cell chemosensitivity Be aware and avoid concomitant use... 

Subacute EmoElients are the mainstay of treatment. Zinc oxide cream or paste, with mild keratolytic if skin thickening present (salicylic add or coal tar added) topical corticosteroid ointment. Gamolenic acid (Epogam, evening primrose oil) is of unproven benefic. 

Mastalgia may benefit from gamolenic acid (in evening primrose oil), danazol and bromocriptine or from a combined contraceptive pill. 

Cyclical breast pain or mastalgia, when severe, may respond to continuous use of gamolenic acid (Efamast) (orally) it is an essential unsaturated fatty acid for cell membranes (patients have low concentrations) it may act by reducing cellular uptake of prolaction and ovarian hormones. Danazol and bromocriptine also help. 

Anonymous. Gamolenic acid. Withdrawal of marketing authorizations. WHO Pharmaceuticals Newslett 2002 4 2. 

C18H30O2 M 278.434 (Z,Z,Z) form [506-26-3] y-Linolenic acid. Gamolenic acid, ban, usan Isol. from evening primrose seed oil. A minor component of many animal lipids. Antihypercholesterolemic drug. Hexabromide Mp 196 dec. 

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