Hormones antagonists

A few typical examples of hormone antagonists are discussed below. [Pg.870]

Antiestrongens are such compounds which block the oestrogen activity. Compounds belonging to this category are essentially the structural analogues of the oestrogen triphenylethylene. [Pg.870]

It is employed as an alternative to androgens and oestrogens in the management of breast cancer. It is also used to stimulate ovulation in infertility. [Pg.870]

Dose For breast cancer oral, 10 to 20 mg of tamoxifen twice daily (or 20 to 40 mg daily) For stimulating ovulation usual, 10 mg of tamoxifen two times per day on day 2, 3, 4 and 5 of the menstrual cycle, alternatively single daily doses of 20 to 80 mg may be employed on the same days. [Pg.870]

Nitromifene gets converted to its corresponding phenolic metabolite (methoxy moiety changes to phenolic OH group) which displays a high affinity for the oestrogen receptor. [Pg.871]

Tumors derived from hormone sensitive tissues may remain hormone dependent and are then amenable to therapeutic approaches with hormonal agents. These include hormones with opposing (apoptotic) action, hormone antagonists, and agents that inhibit hormone synthesis. [Pg.155]

Hormone antagonists (tamoxifen and toremifen bind to the estradiol receptor, flutamide binds to the androgen receptor) are used for treating breast and prostate cancer. [Pg.155]

Flototto, T. Djahansouzi, S. Glaser, M. Hanstein, B. Niederacher, D. Brumm, C. Beckmann, M. W. Hormones and hormone antagonists mechanisms of action in carcinogenesis of endometrial and breast cancer. Horm. Metab. Res. 2001, 33, 451 -57. [Pg.355]

Abarelix is a gonadotropin-releasing hormone antagonist that is associated with life-threatening hypersensitivity reactions. Patients must be observed for 30 minutes after administration. The drug is limited to men who cannot risk tumor flare and refuse orchiectomy. [Pg.1296]

Conn, P.M., Rogers, D.C., Stewart, J.M., Niedel, J., and Sheffield, T. (1982a) Conversion of a gonadotropin-releasing hormone antagonist to an agonist. Nature (London) 296, 633-655. [Pg.1056]

Hormone Antagonists and modulators—includes aromatase inhibitors such as anastrazole... [Pg.226]

The luteinizing hormone releasing hormone antagonist RS-26306 (Fig. 6.19) is another example of a peptide analogue that undergoes hydrolysis of its terminal CONH2 group. This decapeptide contains five synthetic amino... [Pg.296]

Using hormone antagonists that block the binding of angiotensin II to its receptors. [Pg.330]

Jordan V (1982) Hormone Antagonists. In Agarwal MK (ed) de Gruyter, Berlin, New... [Pg.60]

Hormone Antagonists - Blockade of Steroid Hormone Receptors... [Pg.51]

Propylthiouracil [PTU] [Antithyroid Agent/Thyroid Hormone Antagonist] Uses HypCTthyroidism Action X Production of Tg T4 conversion of T4 to Tg Dose Adults. Initial 100 mg PO q8h (may need up... [Pg.267]

See also in sourсe #XX -- [ Pg.50 ]

See also in sourсe #XX -- [ Pg.50 ]

See also in sourсe #XX -- [ Pg.21 , Pg.51 ]

See also in sourсe #XX -- [ Pg.447 ]

See also in sourсe #XX -- [ Pg.155 ]

See also in sourсe #XX -- [ Pg.856 , Pg.905 , Pg.906 , Pg.907 ]

See also in sourсe #XX -- [ Pg.865 , Pg.870 , Pg.874 ]

See also in sourсe #XX -- [ Pg.313 , Pg.314 ]

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