Anti-hormones

Cells from tissues associated with primary and secondary sexual characteristics are under particular endocrine control. Sex hormones determinethe growth, differentiation, and proliferation of such cells. When a tumor develops in such tissues, it is sometimes hormone dependent and the use of anti hormones removes the impetus for the tumor s headlong growth. Many nonsteroidal compounds have estrogenic activity diethylstilbest-jrol (81) may be taken as an example. Certain more bulky an-... 

In the opening chapter, Drs. Jens Hoffmann and Anette Sommer summarise recent advances in anti-hormonal research, a more longstanding area of therapy where significant opportunities still remain for novel or improved drugs. The following two chapters review inhibitors of cell growth and proUf-eration Drs. Eli Wallace, Ellen Laird, Tammie Yeh, James Blake and Joseph... 

Anti-hormone Therapy Principles of Endocrine Therapy of Cancer... 

Enzymes that are involved in steroid hormone biosynthesis or in steroid metabolism are also targets of anti-hormonal therapy. Recently, it was discovered that certain co-factors modulate the signalling of steroid hormone receptors in a tissue-selective fashion. By binding the receptor ligand complex, these co-activators and co-repressors are capable of either activating or repressing transcription, respectively [5j. 

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